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Association of HER2 overexpression and prognosis in small (T1N0) primary breast cancers

Background: There is some controversy regarding the precise role and need for adjuvant therapy in patients with pT1a/pT1bN0 breast cancer, although studies have indicated that a HER2-positive status is one of the most powerful poor prognostic factors. Patients and Methods: We retrospectively evaluat...

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Hauptverfasser: Rom, Joachim (VerfasserIn) , Schumacher, Claudia (VerfasserIn) , Gluz, Oleg (VerfasserIn) , Höfler, Josef (VerfasserIn) , Eidt, Sebastian (VerfasserIn) , Domschke, Christoph (VerfasserIn) , Marmé, Frederik (VerfasserIn) , Nitz, Ulrike (VerfasserIn) , Sohn, Christof (VerfasserIn) , Schneeweiss, Andreas (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: June 22, 2013
In: Breast care
Year: 2013, Jahrgang: 8, Heft: 3, Pages: 208-214
ISSN:1661-3805
DOI:10.1159/000352094
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1159/000352094
Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/352094
Volltext
Verfasserangaben:Joachim Rom, Claudia Schumacher, Oleg Gluz, Josef Höfler, Sebastian Eidt, Christoph Domschke, Frederik Marmé, Ulrike Nitz, Christof Sohn, Andreas Schneeweiss
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Zusammenfassung:Background: There is some controversy regarding the precise role and need for adjuvant therapy in patients with pT1a/pT1bN0 breast cancer, although studies have indicated that a HER2-positive status is one of the most powerful poor prognostic factors. Patients and Methods: We retrospectively evaluated disease-free survival (DFS), distant disease-free survival (DDFS), and overall survival (OS) among 960 patients diagnosed between 2000 and 2008 with T1N0 primary breast cancer treated at 3 German centers, and determined prognostic risk factors. Univariate analysis was used to determine associations with potential risk factors. Results: With a median follow-up of 23 months, DFS was 94.8%, DDFS 96.3%, and OS 97.5%. Risk factors for decreased 1-year DFS were: peritumoral lymphatic invasion (L1) (p = 0.031), negative hormone receptor status (p = 0.003), non-use of hormonal therapy (p = 0.001), and a positive HER2 status (p = 0.003). Amongst the HER2-positive patients only 2.7% (n = 1/37) of those treated with trastuzumab had a DFS event compared with 20% (n = 10/50) without trastuzumab. Conclusion: Patients with HER2-positive T1 breast cancer should be considered for inclusion in prospective trials of trastuzumab in combination with chemotherapy to determine the risk-to-benefit ratio and association with other prognostic factors.
Beschreibung:Gesehen am 19.01.2022
Beschreibung:Online Resource
ISSN:1661-3805
DOI:10.1159/000352094

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