Characterization of atherosclerotic plaques in blood vessels with low oxygenated blood and blood pressure (pulmonary trunk): role of growth differentiation factor-15 (GDF-15)
Growth differentiation factor (GDF)-15 is linked to inflammation, cancer, and atherosclerosis. GDF-15 is expressed in most tissues but is extremely induced under pathological conditions. Elevated serum levels are suggested as a risk factor and a marker for cardiovascular diseases. However, the cellu...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 December 2021
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| In: |
BMC cardiovascular disorders
Year: 2021, Volume: 21, Issue: 1, Pages: 1-16 |
| ISSN: | 1471-2261 |
| DOI: | 10.1186/s12872-021-02420-9 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s12872-021-02420-9
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| Author Notes: | G.A. Bonaterra, N. Struck, S. Zuegel, A. Schwarz, L. Mey, H. Schwarzbach, J. Strelau, R. Kinscherf |
| Summary: | Growth differentiation factor (GDF)-15 is linked to inflammation, cancer, and atherosclerosis. GDF-15 is expressed in most tissues but is extremely induced under pathological conditions. Elevated serum levels are suggested as a risk factor and a marker for cardiovascular diseases. However, the cellular sources and the effects of GDF-15 on the cardiovascular system have not been completely elucidated including progression, and morphology of atherosclerotic plaques. Thus, this work aimed to characterize the influence of GDF-15 deficiency on the morphology of atherosclerotic plaques in blood vessels with low-oxygen blood and low blood pressure as the pulmonary trunk (PT), in hypercholesterolemic ApoE−/− mice. |
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| Item Description: | Gesehen am 20.01.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1471-2261 |
| DOI: | 10.1186/s12872-021-02420-9 |