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Gene therapy for sarcoma

Soft tissue sarcomas are mesenchymal tumors which respond poorly to systemic therapy. Recent studies suggest a higher response rate with an increased doxorubicin dosage. However, this was parallel with a profound hematotoxicity in 75% of patients. Transfer of the human multidrug resistance 1 (MDR1)...

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Main Authors: Frühauf, Stefan (Author) , Veldwijk, Marlon Romano (Author) , Berlinghoff, S. (Author) , Basara, N. (Author) , Baum, C. (Author) , Flasshove, M. (Author) , Hegewisch-Becker, S. (Author) , Kröger, N. (Author) , Licht, T. (Author) , Moritz, T. (Author) , Hengge, U. R. (Author) , Zeller, W. Jens (Author) , Maier-Laufs, Stephanie (Author)
Format: Article (Journal)
Language:English
Published: November 10, 2002
In: Cells tissues organs
Year: 2002, Volume: 172, Issue: 2, Pages: 133-144
ISSN:1422-6421
DOI:10.1159/000065614
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1159/000065614
Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/65614
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Author Notes:S. Fruehauf, M.R. Veldwijk, S. Berlinghoff, N. Basara, C. Baum, M. Flasshove, S. Hegewisch-Becker, N. Kröger, T. Licht, T. Moritz, U.R. Hengge, W. Jens Zeller, S. Laufs
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Summary:Soft tissue sarcomas are mesenchymal tumors which respond poorly to systemic therapy. Recent studies suggest a higher response rate with an increased doxorubicin dosage. However, this was parallel with a profound hematotoxicity in 75% of patients. Transfer of the human multidrug resistance 1 (MDR1) gene to normal hematopoietic stem cells and transplantation may significantly reduce the hematotoxicity of anthracyclin-based chemotherapy.
Item Description:Gesehen am 20.01.2022
Physical Description:Online Resource
ISSN:1422-6421
DOI:10.1159/000065614

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