Gene therapy for sarcoma
Soft tissue sarcomas are mesenchymal tumors which respond poorly to systemic therapy. Recent studies suggest a higher response rate with an increased doxorubicin dosage. However, this was parallel with a profound hematotoxicity in 75% of patients. Transfer of the human multidrug resistance 1 (MDR1)...
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| Hauptverfasser: | , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
November 10, 2002
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| In: |
Cells tissues organs
Year: 2002, Jahrgang: 172, Heft: 2, Pages: 133-144 |
| ISSN: | 1422-6421 |
| DOI: | 10.1159/000065614 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1159/000065614 Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/65614 |
| Verfasserangaben: | S. Fruehauf, M.R. Veldwijk, S. Berlinghoff, N. Basara, C. Baum, M. Flasshove, S. Hegewisch-Becker, N. Kröger, T. Licht, T. Moritz, U.R. Hengge, W. Jens Zeller, S. Laufs |
| Zusammenfassung: | Soft tissue sarcomas are mesenchymal tumors which respond poorly to systemic therapy. Recent studies suggest a higher response rate with an increased doxorubicin dosage. However, this was parallel with a profound hematotoxicity in 75% of patients. Transfer of the human multidrug resistance 1 (MDR1) gene to normal hematopoietic stem cells and transplantation may significantly reduce the hematotoxicity of anthracyclin-based chemotherapy. |
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| Beschreibung: | Gesehen am 20.01.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 1422-6421 |
| DOI: | 10.1159/000065614 |