Relevance of peripheral blood progenitor cell counts during steady-state hematopoiesis to estimate the number of progenitor cells mobilized following granulocyte colony-stimulating factor-supported chemotherapy
Peripheral blood progenitor cells can be mobilized using cytotoxic chemotherapy and cytokines. We were looking for predictive parameters indicating a patient’s response to a given mobilization regimen. Patients and Methods: Flow cytometry analysis and clonogenic assays were used to examine hematopoi...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
April 13, 1999
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| In: |
Infusion therapy and transfusion medicine
Year: 1999, Volume: 26, Issue: 2, Pages: 103-109 |
| ISSN: | 1424-5493 |
| DOI: | 10.1159/000053472 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1159/000053472 Verlag, lizenzpflichtig, Volltext: https://www.karger.com/Article/FullText/53472 
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| Author Notes: | S. Fruehauf, K. Schmitt, M.R. Veldwijk, B. Schiedlmeier, S. Martin, W.J. Zeller, R. Haas |
| Summary: | Peripheral blood progenitor cells can be mobilized using cytotoxic chemotherapy and cytokines. We were looking for predictive parameters indicating a patient’s response to a given mobilization regimen. Patients and Methods: Flow cytometry analysis and clonogenic assays were used to examine hematopoietic progenitor cells in bone marrow and peripheral blood prior to G-CSF-supported chemotherapy and were compared to CD34+ cell counts in peripheral blood and leukapheresis products in the recovery phase. Stroma-dependent long-term cultures were performed from steady-state bone marrow and leukapheresis product samples. 90 patients (24 non-Hodgkin’s lymphoma, 5 Hodgkin’s disease, 33 multiple myeloma, 28 solid tumor) were included in this study. |
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| Item Description: | Gesehen am 21.01.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1424-5493 |
| DOI: | 10.1159/000053472 |