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High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas

Translocations affecting chromosome subband 6p25.3 containing the IRF4 gene have been recently described as characteristic alterations in a molecularly distinct subset of germinal center B-cell-derived lymphomas. Secondary changes have yet only been described in few of these lymphomas. Here, we perf...

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Main Authors: Salaverria, Itziar (Author) , Martin-Guerrero, Idoia (Author) , Burkhardt, Birgit (Author) , Kreuz, Markus (Author) , Zenz, Thorsten (Author) , Oschlies, Ilske (Author) , Arnold, Norbert (Author) , Baudis, Michael (Author) , Bens, Susanne (Author) , García-Orad, Africa (Author) , Lisfeld, Jasmin (Author) , Schwaenen, Carsten (Author) , Szczepanowski, Monika (Author) , Wessendorf, Swen (Author) , Pfreundschuh, Michael (Author) , Trümper, Lorenz (Author) , Klapper, Wolfram (Author) , Siebert, Reiner (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: Genes, chromosomes & cancer
Year: 2013, Volume: 52, Issue: 2, Pages: 150-155
ISSN:1098-2264
DOI:10.1002/gcc.22014
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/gcc.22014
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/gcc.22014
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Author Notes:Itziar Salaverria, Idoia Martin-Guerrero, Birgit Burkhardt, Markus Kreuz, Thorsten Zenz, Ilske Oschlies, Norbert Arnold, Michael Baudis, Susanne Bens, Africa García-Orad, Jasmin Lisfeld, Carsten Schwaenen, Monika Szczepanowski, Swen Wessendorf, Michael Pfreundschuh, Lorenz Trümper, Wolfram Klapper, Reiner Siebert
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Summary:Translocations affecting chromosome subband 6p25.3 containing the IRF4 gene have been recently described as characteristic alterations in a molecularly distinct subset of germinal center B-cell-derived lymphomas. Secondary changes have yet only been described in few of these lymphomas. Here, we performed array-comparative genomic hybridization and molecular inversion probe microarray analyses on DNA from 12 formalin-fixed paraffin-embedded and two fresh-frozen IRF4 translocation-positive lymphomas, which together with the previously published data on nine cases allowed the extension of copy number analyses to a total of 23 of these lymphomas. All except one case carried chromosomal imbalances, most frequently gains in Xq28, 11q22.3-qter, and 7q32.1-qter and losses in 6q13-16.1, 15q14-22.31, and 17p. No recurrent copy-neutral losses of heterozygosity were observed. TP53 point mutations were detected in three of six cases with loss of 17p. Overall this study unravels a recurrent pattern of secondary genetic alterations in IRF4 translocation-positive lymphomas. © 2012 Wiley Periodicals, Inc.
Item Description:First published: 17 October 2012
Gesehen am 26.01.2022
Physical Description:Online Resource
ISSN:1098-2264
DOI:10.1002/gcc.22014

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