High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas
Translocations affecting chromosome subband 6p25.3 containing the IRF4 gene have been recently described as characteristic alterations in a molecularly distinct subset of germinal center B-cell-derived lymphomas. Secondary changes have yet only been described in few of these lymphomas. Here, we perf...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2013
|
| In: |
Genes, chromosomes & cancer
Year: 2013, Jahrgang: 52, Heft: 2, Pages: 150-155 |
| ISSN: | 1098-2264 |
| DOI: | 10.1002/gcc.22014 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/gcc.22014 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/gcc.22014 
|
| Verfasserangaben: | Itziar Salaverria, Idoia Martin-Guerrero, Birgit Burkhardt, Markus Kreuz, Thorsten Zenz, Ilske Oschlies, Norbert Arnold, Michael Baudis, Susanne Bens, Africa García-Orad, Jasmin Lisfeld, Carsten Schwaenen, Monika Szczepanowski, Swen Wessendorf, Michael Pfreundschuh, Lorenz Trümper, Wolfram Klapper, Reiner Siebert |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 178719020X | ||
| 003 | DE-627 | ||
| 005 | 20220820113806.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220126s2013 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1002/gcc.22014 |2 doi | |
| 035 | |a (DE-627)178719020X | ||
| 035 | |a (DE-599)KXP178719020X | ||
| 035 | |a (OCoLC)1341439212 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Salaverria, Itziar |e VerfasserIn |0 (DE-588)1084033712 |0 (DE-627)848242505 |0 (DE-576)456171649 |4 aut | |
| 245 | 1 | 0 | |a High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas |c Itziar Salaverria, Idoia Martin-Guerrero, Birgit Burkhardt, Markus Kreuz, Thorsten Zenz, Ilske Oschlies, Norbert Arnold, Michael Baudis, Susanne Bens, Africa García-Orad, Jasmin Lisfeld, Carsten Schwaenen, Monika Szczepanowski, Swen Wessendorf, Michael Pfreundschuh, Lorenz Trümper, Wolfram Klapper, Reiner Siebert |
| 264 | 1 | |c 2013 | |
| 300 | |a 6 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a First published: 17 October 2012 | ||
| 500 | |a Gesehen am 26.01.2022 | ||
| 520 | |a Translocations affecting chromosome subband 6p25.3 containing the IRF4 gene have been recently described as characteristic alterations in a molecularly distinct subset of germinal center B-cell-derived lymphomas. Secondary changes have yet only been described in few of these lymphomas. Here, we performed array-comparative genomic hybridization and molecular inversion probe microarray analyses on DNA from 12 formalin-fixed paraffin-embedded and two fresh-frozen IRF4 translocation-positive lymphomas, which together with the previously published data on nine cases allowed the extension of copy number analyses to a total of 23 of these lymphomas. All except one case carried chromosomal imbalances, most frequently gains in Xq28, 11q22.3-qter, and 7q32.1-qter and losses in 6q13-16.1, 15q14-22.31, and 17p. No recurrent copy-neutral losses of heterozygosity were observed. TP53 point mutations were detected in three of six cases with loss of 17p. Overall this study unravels a recurrent pattern of secondary genetic alterations in IRF4 translocation-positive lymphomas. © 2012 Wiley Periodicals, Inc. | ||
| 700 | 1 | |a Martin-Guerrero, Idoia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Burkhardt, Birgit |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kreuz, Markus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zenz, Thorsten |d 1970- |e VerfasserIn |0 (DE-588)114963738 |0 (DE-627)577184202 |0 (DE-576)180278266 |4 aut | |
| 700 | 1 | |a Oschlies, Ilske |e VerfasserIn |4 aut | |
| 700 | 1 | |a Arnold, Norbert |e VerfasserIn |4 aut | |
| 700 | 1 | |a Baudis, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bens, Susanne |e VerfasserIn |4 aut | |
| 700 | 1 | |a García-Orad, Africa |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lisfeld, Jasmin |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schwaenen, Carsten |e VerfasserIn |4 aut | |
| 700 | 1 | |a Szczepanowski, Monika |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wessendorf, Swen |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pfreundschuh, Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Trümper, Lorenz |e VerfasserIn |4 aut | |
| 700 | 1 | |a Klapper, Wolfram |e VerfasserIn |4 aut | |
| 700 | 1 | |a Siebert, Reiner |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Genes, chromosomes & cancer |d New York, NY : Wiley-Liss, 1989 |g 52(2013), 2 vom: Feb., Seite 150-155 |h Online-Ressource |w (DE-627)302922369 |w (DE-600)1492641-6 |w (DE-576)094400474 |x 1098-2264 |7 nnas |a High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas |
| 773 | 1 | 8 | |g volume:52 |g year:2013 |g number:2 |g month:02 |g pages:150-155 |g extent:6 |a High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas |
| 856 | 4 | 0 | |u https://doi.org/10.1002/gcc.22014 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://onlinelibrary.wiley.com/doi/abs/10.1002/gcc.22014 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220126 | ||
| 993 | |a Article | ||
| 994 | |a 2013 | ||
| 998 | |g 114963738 |a Zenz, Thorsten |m 114963738:Zenz, Thorsten |p 5 | ||
| 999 | |a KXP-PPN178719020X |e 4044746192 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"name":{"displayForm":["Itziar Salaverria, Idoia Martin-Guerrero, Birgit Burkhardt, Markus Kreuz, Thorsten Zenz, Ilske Oschlies, Norbert Arnold, Michael Baudis, Susanne Bens, Africa García-Orad, Jasmin Lisfeld, Carsten Schwaenen, Monika Szczepanowski, Swen Wessendorf, Michael Pfreundschuh, Lorenz Trümper, Wolfram Klapper, Reiner Siebert"]},"id":{"doi":["10.1002/gcc.22014"],"eki":["178719020X"]},"origin":[{"dateIssuedKey":"2013","dateIssuedDisp":"2013"}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"origin":[{"dateIssuedDisp":"1989-","publisher":"Wiley-Liss","dateIssuedKey":"1989","publisherPlace":"New York, NY"}],"id":{"issn":["1098-2264"],"zdb":["1492641-6"],"eki":["302922369"],"doi":["10.1002/(ISSN)1098-2264"]},"type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 14.12.07"],"disp":"High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomasGenes, chromosomes & cancer","recId":"302922369","language":["eng"],"pubHistory":["1.1989/90 -"],"part":{"pages":"150-155","issue":"2","year":"2013","extent":"6","volume":"52","text":"52(2013), 2 vom: Feb., Seite 150-155"},"title":[{"title_sort":"Genes, chromosomes & cancer","title":"Genes, chromosomes & cancer"}]}],"physDesc":[{"extent":"6 S."}],"person":[{"roleDisplay":"VerfasserIn","display":"Salaverria, Itziar","role":"aut","family":"Salaverria","given":"Itziar"},{"family":"Martin-Guerrero","given":"Idoia","display":"Martin-Guerrero, Idoia","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Burkhardt","given":"Birgit","display":"Burkhardt, Birgit","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","display":"Kreuz, Markus","role":"aut","family":"Kreuz","given":"Markus"},{"roleDisplay":"VerfasserIn","display":"Zenz, Thorsten","role":"aut","family":"Zenz","given":"Thorsten"},{"role":"aut","display":"Oschlies, Ilske","roleDisplay":"VerfasserIn","given":"Ilske","family":"Oschlies"},{"role":"aut","display":"Arnold, Norbert","roleDisplay":"VerfasserIn","given":"Norbert","family":"Arnold"},{"given":"Michael","family":"Baudis","role":"aut","display":"Baudis, Michael","roleDisplay":"VerfasserIn"},{"family":"Bens","given":"Susanne","display":"Bens, Susanne","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"García-Orad, Africa","given":"Africa","family":"García-Orad"},{"family":"Lisfeld","given":"Jasmin","display":"Lisfeld, Jasmin","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Schwaenen, Carsten","roleDisplay":"VerfasserIn","given":"Carsten","family":"Schwaenen"},{"role":"aut","display":"Szczepanowski, Monika","roleDisplay":"VerfasserIn","given":"Monika","family":"Szczepanowski"},{"display":"Wessendorf, Swen","roleDisplay":"VerfasserIn","role":"aut","family":"Wessendorf","given":"Swen"},{"given":"Michael","family":"Pfreundschuh","role":"aut","roleDisplay":"VerfasserIn","display":"Pfreundschuh, Michael"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Trümper, Lorenz","given":"Lorenz","family":"Trümper"},{"family":"Klapper","given":"Wolfram","roleDisplay":"VerfasserIn","display":"Klapper, Wolfram","role":"aut"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Siebert, Reiner","given":"Reiner","family":"Siebert"}],"title":[{"title_sort":"High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas","title":"High resolution copy number analysis of IRF4 translocation-positive diffuse large B-cell and follicular lymphomas"}],"recId":"178719020X","language":["eng"],"note":["First published: 17 October 2012","Gesehen am 26.01.2022"],"type":{"media":"Online-Ressource","bibl":"article-journal"}} | ||
| SRT | |a SALAVERRIAHIGHRESOLU2013 | ||