Hypothermia inhibits expression of CD11b (MAC-1) and CD162 (PSGL-1) on monocytes during extracorporeal circulation
Aim: The aim of the present study was to investigate the effect of different hypothermic temperatures on the expression of cellular adhesion molecules on leukocytes. Materials and Methods: Circulation of blood from six volunteers was performed in an extracorporeal circulation model at 36°C, 28°C and...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 30, 2013
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| In: |
In vivo
Year: 2013, Jahrgang: 27, Heft: 4, Pages: 459-464 |
| ISSN: | 1791-7549 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://iv.iiarjournals.org/content/27/4/459
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| Verfasserangaben: | Stefanie Swoboda, Joachim Gruettner, Siegfried Lang, Hans-Peter Wendel, Martin E. Beyer, Eva Griesel, Hans-Martin Hoffmeister, and Thomas Walter |
| Zusammenfassung: | Aim: The aim of the present study was to investigate the effect of different hypothermic temperatures on the expression of cellular adhesion molecules on leukocytes. Materials and Methods: Circulation of blood from six volunteers was performed in an extracorporeal circulation model at 36°C, 28°C and 18°C for 30 minutes. Expression of CD11b, CD54 and CD162 on monocytes was measured using flow cytometry. Results: Expression of CD11b significantly decreased at 18°C and at 28°C compared to 36°C. A significant reduction of CD162 expression was found at 18°C compared to 28°C and 36°C and at 28°C compared to 36°C. No association was found between temperature and expression of CD54. Conclusion: Expression of CD11b and CD162 on monocytes has a temperature-dependent regulation, with decreased expression during hypothermia, which may result in an inhibition of leukocyte-endothelial and leukocyte-platelet interaction. This beneficial effect may influence the extracorporeal circulation-related inflammatory response and tissue damage. |
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| Beschreibung: | Gesehen am 27.01.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 1791-7549 |