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Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case-control studies

Background Tubal ligation is a protective factor for ovarian cancer, but it is unknown whether this protection extends to all invasive histological subtypes or borderline tumors. We undertook an international collaborative study to examine the association between tubal ligation and ovarian cancer su...

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Main Authors: Sieh, Weiva (Author) , Salvador, Shannon (Author) , McGuire, Valerie (Author) , Weber, Rachel Palmieri (Author) , Terry, Kathryn L (Author) , Rossing, Mary Anne (Author) , Risch, Harvey (Author) , Wu, Anna H (Author) , Webb, Penelope M (Author) , Moysich, Kirsten (Author) , Doherty, Jennifer A (Author) , Felberg, Anna (Author) , Miller, Dianne (Author) , Jordan, Susan J (Author) , Goodman, Marc T (Author) , Lurie, Galina (Author) , Chang-Claude, Jenny (Author) , Rudolph, Anja (Author) , Kjær, Susanne Krüger (Author) , Jensen, Allan (Author) , Høgdall, Estrid (Author) , Bandera, Elisa V (Author) , Olson, Sara H (Author) , King, Melony G (Author) , Rodriguez-Rodriguez, Lorna (Author) , Kiemeney, Lambertus A (Author) , Marees, Tamara (Author) , Massuger, Leon F (Author) , van Altena, Anne M (Author) , Ness, Roberta B (Author) , Cramer, Daniel W (Author) , Pike, Malcolm C (Author) , Pearce, Celeste Leigh (Author) , Berchuck, Andrew (Author) , Schildkraut, Joellen M (Author) , Whittemore, Alice S (Author)
Corporate Authors: Australian Cancer Study (Ovarian Cancer) (Author) , Australian Ovarian Cancer Study Group (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: International journal of epidemiology
Year: 2013, Volume: 42, Issue: 2, Pages: 579-589
ISSN:1464-3685
DOI:10.1093/ije/dyt042
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1093/ije/dyt042
Verlag, lizenzpflichtig, Volltext: https://academic.oup.com/ije/article/42/2/579/738696
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Author Notes:Weiva Sieh, Shannon Salvador, Valerie McGuire, Rachel Palmieri Weber, Kathryn L Terry, Mary Anne Rossing, Harvey Risch, Anna H Wu, Penelope M Webb, Kirsten Moysich, Jennifer A Doherty, Anna Felberg, Dianne Miller, Susan J Jordan, Australian Cancer Study (Ovarian Cancer), Australian Ovarian Cancer Study Group, Marc T Goodman, Galina Lurie, Jenny Chang-Claude, Anja Rudolph, Susanne Krüger Kjær, Allan Jensen, Estrid Høgdall, Elisa V Bandera, Sara H Olson, Melony G King, Lorna Rodriguez-Rodriguez, Lambertus A Kiemeney, Tamara Marees, Leon F Massuger, Anne M van Altena, Roberta B Ness, Daniel W Cramer, Malcolm C Pike, Celeste Leigh Pearce, Andrew Berchuck, Joellen M Schildkraut, Alice S Whittemore, on behalf of the Ovarian Cancer Association Consortium
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Summary:Background Tubal ligation is a protective factor for ovarian cancer, but it is unknown whether this protection extends to all invasive histological subtypes or borderline tumors. We undertook an international collaborative study to examine the association between tubal ligation and ovarian cancer subtypes.Methods We pooled primary data from 13 population-based case-control studies, including 10 157 patients with ovarian cancer (7942 invasive; 2215 borderline) and 13 904 control women. Invasive cases were analysed by histological type, grade and stage, and borderline cases were analysed by histological type. Pooled odds ratios were estimated using conditional logistic regression to match on site, race/ethnicity and age categories, and to adjust for age, oral contraceptive use duration and number of full-term births.Results Tubal ligation was associated with significantly reduced risks of invasive serous (OR, 0.81; 95% CI, 0.74-0.89; P < 0.001), endometrioid (OR, 0.48; 95% CI, 0.40-0.59; P < 0.001), clear cell (OR, 0.52; 95% CI, 0.40-0.67; P < 0.001) and mucinous (OR, 0.68; 95% CI, 0.52-0.89; P = 0.005) cancers. The magnitude of risk reduction was significantly greater for invasive endometrioid (P < 0.0001) and clear cell (P = 0.0018) than for serous cancer. No significant associations were found with borderline serous or mucinous tumours.Conclusions We found that the protective effects of tubal ligation on ovarian cancer risk were subtype-specific. These findings provide insights into distinct aetiologies of ovarian cancer subtypes and mechanisms underlying the protective effects of tubal ligation.
Item Description:Published: 05 April 2013
Gesehen am 27.01.2022
Physical Description:Online Resource
ISSN:1464-3685
DOI:10.1093/ije/dyt042

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