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The accuracy of helium ion CT based particle therapy range prediction: an experimental study comparing different particle and x-ray CT modalities

This work provides a quantitative assessment of helium ion CT (HeCT) for particle therapy treatment planning. For the first time, HeCT based range prediction accuracy in a heterogeneous tissue phantom is presented and compared to single-energy x-ray CT (SECT), dual-energy x-ray CT (DECT) and proton...

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Hauptverfasser: Volz, Lennart (VerfasserIn) , Collins-Fekete, C.-A. (VerfasserIn) , Bär, E. (VerfasserIn) , Brons, Stephan (VerfasserIn) , Graeff, C. (VerfasserIn) , Johnson, R. P. (VerfasserIn) , Runz, Armin (VerfasserIn) , Sarosiek, C. (VerfasserIn) , Schulte, R. W. (VerfasserIn) , Seco, Joao (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 29 November 2021
In: Physics in medicine and biology
Year: 2021, Jahrgang: 66, Heft: 23, Pages: 1-17
ISSN:1361-6560
DOI:10.1088/1361-6560/ac33ec
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1088/1361-6560/ac33ec
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Verfasserangaben:L Volz, C-A Collins-Fekete, E Bär, S Brons, C Graeff, RP Johnson, A Runz, C Sarosiek, RW Schulte and J Seco
Beschreibung
Zusammenfassung:This work provides a quantitative assessment of helium ion CT (HeCT) for particle therapy treatment planning. For the first time, HeCT based range prediction accuracy in a heterogeneous tissue phantom is presented and compared to single-energy x-ray CT (SECT), dual-energy x-ray CT (DECT) and proton CT (pCT). HeCT and pCT scans were acquired using the US pCT collaboration prototype particle CT scanner at the Heidelberg Ion-Beam Therapy Center. SECT and DECT scans were done with a Siemens Somatom Definition Flash and converted to RSP. A Catphan CTP404 module was used to study the RSP accuracy of HeCT. A custom phantom of 20 cm diameter containing several tissue equivalent plastic cubes was used to assess the spatial resolution of HeCT and compare it to DECT. A clinically realistic heterogeneous tissue phantom was constructed using cranial slices from a pig head placed inside a cylindrical phantom (ø150 mm). A proton beam (84.67 mm range) depth-dose measurement was acquired using a stack of GafchromicTM EBT-XD films in a central dosimetry insert in the phantom. CT scans of the phantom were acquired with each modality, and proton depth-dose estimates were simulated based on the reconstructions. The RSP accuracy of HeCT for the plastic phantom was found to be 0.3 ± 0.1%. The spatial resolution for HeCT of the cube phantom was 5.9 ± 0.4 lp cm−1 for central, and 7.6 ± 0.8 lp cm−1 for peripheral cubes, comparable to DECT spatial resolution (7.7 ± 0.3 lp cm−1 and 7.4 ± 0.2 lp cm−1, respectively). For the pig head, HeCT, SECT, DECT and pCT predicted range accuracy was 0.25%, −1.40%, −0.45% and 0.39%, respectively. In this study, HeCT acquired with a prototype system showed potential for particle therapy treatment planning, offering RSP accuracy, spatial resolution, and range prediction accuracy comparable to that achieved with a commercial DECT scanner. Still, technical improvements of HeCT are needed to enable clinical implementation.
Beschreibung:Gesehen am 27.01.2022
Beschreibung:Online Resource
ISSN:1361-6560
DOI:10.1088/1361-6560/ac33ec

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