Cover Image

Microarray-based understanding of normal and malignant plasma cells

Summary: Plasma cells (PCs) develop from B lymphocytes following stimulation by antigen and express a genetic program aimed at the synthesis of immunoglobulins. This program includes the induction of genes coding for transcription factors such as PRDM1, X-box-binding protein 1 and BHLHB3, cell-surfa...

Full description

Saved in:
Bibliographic Details
Main Authors: De Vos, John (Author) , Hose, Dirk (Author) , Rème, Thierry (Author) , Tarte, Karin (Author) , Moreaux, Jérôme (Author) , Mahtouk, Karéne (Author) , Jourdan, Michel (Author) , Goldschmidt, Hartmut (Author) , Rossi, Jean-François (Author) , Cremer, Friedrich Walter (Author) , Klein, Bernard (Author)
Format: Article (Journal)
Language:English
Published: 28 March 2006
In: Immunological reviews
Year: 2006, Volume: 210, Issue: 1, Pages: 86-104
ISSN:1600-065X
DOI:10.1111/j.0105-2896.2006.00362.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.0105-2896.2006.00362.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.0105-2896.2006.00362.x
Get full text
Author Notes:John De Vos, Dirk Hose, Thierry Rème, Karin Tarte, Jérôme Moreaux, Karéne Mahtouk, Michel Jourdan, Hartmut Goldschmidt, Jean-François Rossi, Friedrich W. Cremer, Bernard Klein
Description
Summary:Summary: Plasma cells (PCs) develop from B lymphocytes following stimulation by antigen and express a genetic program aimed at the synthesis of immunoglobulins. This program includes the induction of genes coding for transcription factors such as PRDM1, X-box-binding protein 1 and BHLHB3, cell-surface molecules such as CD138/syndecan-1, and for the unfolded protein response. We review how the microarray technology has recently contributed to the understanding of the biology of this rare but essential cell population and its transformation into premalignant and malignant PCs.
Item Description:Gesehen am 28.01.2022
Physical Description:Online Resource
ISSN:1600-065X
DOI:10.1111/j.0105-2896.2006.00362.x

Similar Items