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Domino decarboxylative arylation and c-o selective bond formation toward chromeno(2,3-b)pyridine-2-one skeletons

Practical Pd-catalyzed 2-pyridones were designed to achieve chromeno(2,3-b)pyridine-2-ones. The reaction proceeds through domino nucleophilic addition and decarboxylative arylation, respectively. This methodology offers a moderately efficient approach to construct the bioactive, fused-heterocyclic s...

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Main Authors: Ahadi, Elmira Meghrazi (Author) , Abbasi Kejani, Alireza (Author) , Khosravi, Hormoz (Author) , Fathi Vavsari, Vaezeh (Author) , Balalaie, Saeed (Author) , Rominger, Frank (Author) , Bijanzadeh, Hamid Reza (Author)
Format: Article (Journal)
Language:English
Published: September 8, 2021
In: The journal of organic chemistry
Year: 2021, Volume: 86, Issue: 18, Pages: 12705-12713
ISSN:1520-6904
DOI:10.1021/acs.joc.1c01220
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1021/acs.joc.1c01220
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Author Notes:Elmira Meghrazi Ahadi, Alireza Abbasi Kejani, Hormoz Khosravi, Vaezeh Fathi Vavsari, Saeed Balalaie, Frank Rominger, and Hamid Reza Bijanzadeh
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Summary:Practical Pd-catalyzed 2-pyridones were designed to achieve chromeno(2,3-b)pyridine-2-ones. The reaction proceeds through domino nucleophilic addition and decarboxylative arylation, respectively. This methodology offers a moderately efficient approach to construct the bioactive, fused-heterocyclic skeletons via selective C-O bond formation and decarboxylative arylation in a single step with high selectivity and good yields.
Item Description:Gesehen am 01.02.2022
Physical Description:Online Resource
ISSN:1520-6904
DOI:10.1021/acs.joc.1c01220

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