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Wapl is an essential regulator of chromatin structure and chromosome segregation

Depletion of the cohesin-associated protein Wapl in mice is shown to increase the residence time of cohesin on DNA, which leads to clustering of cohesin in axial structures, and causes chromatin condensation in interphase chromosomes; the findings suggest that cohesin could have an architectural rol...

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Autori principali: Tedeschi, Antonio (Autore) , Wutz, Gordana (Autore) , Huet, Sébastien (Autore) , Jaritz, Markus (Autore) , Wünsche, Annelie (Autore) , Schirghuber, Erika (Autore) , Davidson, Iain Finley (Autore) , Tang, Wen (Autore) , Cisneros, David A. (Autore) , Bhaskara, Venugopal (Autore) , Nishiyama, Tomoko (Autore) , Vaziri, Alipasha (Autore) , Wutz, Anton (Autore) , Ellenberg, Jan (Autore) , Peters, Jan-Michael (Autore)
Natura: Article (Journal) Editorial
Lingua:inglese
Pubblicazione: 25 August 2013
In: Nature
Year: 2013, Volume: 501, Fascicolo: 7468, Pages: 564-568
ISSN:1476-4687
DOI:10.1038/nature12471
Accesso online:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature12471
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature12471
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Note sull'autore:Antonio Tedeschi, Gordana Wutz, Sébastien Huet, Markus Jaritz, Annelie Wuensche, Erika Schirghuber, Iain Finley Davidson, Wen Tang, David A. Cisneros, Venugopal Bhaskara, Tomoko Nishiyama, Alipasha Vaziri, Anton Wutz, Jan Ellenberg & Jan-Michael Peters
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Riassunto:Depletion of the cohesin-associated protein Wapl in mice is shown to increase the residence time of cohesin on DNA, which leads to clustering of cohesin in axial structures, and causes chromatin condensation in interphase chromosomes; the findings suggest that cohesin could have an architectural role in interphase chromosome organization.
Descrizione del documento:Gesehen am 03.02.2022
Descrizione fisica:Online Resource
ISSN:1476-4687
DOI:10.1038/nature12471

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