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Wapl is an essential regulator of chromatin structure and chromosome segregation

Depletion of the cohesin-associated protein Wapl in mice is shown to increase the residence time of cohesin on DNA, which leads to clustering of cohesin in axial structures, and causes chromatin condensation in interphase chromosomes; the findings suggest that cohesin could have an architectural rol...

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Main Authors: Tedeschi, Antonio (Author) , Wutz, Gordana (Author) , Huet, Sébastien (Author) , Jaritz, Markus (Author) , Wünsche, Annelie (Author) , Schirghuber, Erika (Author) , Davidson, Iain Finley (Author) , Tang, Wen (Author) , Cisneros, David A. (Author) , Bhaskara, Venugopal (Author) , Nishiyama, Tomoko (Author) , Vaziri, Alipasha (Author) , Wutz, Anton (Author) , Ellenberg, Jan (Author) , Peters, Jan-Michael (Author)
Format: Article (Journal) Editorial
Language:English
Published: 25 August 2013
In: Nature
Year: 2013, Volume: 501, Issue: 7468, Pages: 564-568
ISSN:1476-4687
DOI:10.1038/nature12471
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/nature12471
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/nature12471
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Author Notes:Antonio Tedeschi, Gordana Wutz, Sébastien Huet, Markus Jaritz, Annelie Wuensche, Erika Schirghuber, Iain Finley Davidson, Wen Tang, David A. Cisneros, Venugopal Bhaskara, Tomoko Nishiyama, Alipasha Vaziri, Anton Wutz, Jan Ellenberg & Jan-Michael Peters
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Summary:Depletion of the cohesin-associated protein Wapl in mice is shown to increase the residence time of cohesin on DNA, which leads to clustering of cohesin in axial structures, and causes chromatin condensation in interphase chromosomes; the findings suggest that cohesin could have an architectural role in interphase chromosome organization.
Item Description:Gesehen am 03.02.2022
Physical Description:Online Resource
ISSN:1476-4687
DOI:10.1038/nature12471

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