Multigene assays for classification, prognosis, and prediction in breast cancer: a critical review on the background and clinical utility = Multigenassays zur Beurteilung der Klassifikation, Prognose und Prädiktion beim Mammakarzinom : ein kritischer Review zum Hintergrund und klinischen Nutzen
<p>Gene signatures which are based on multigene profiling assays have been developed for the purpose to better define the prognosis and prediction of therapy results in early-stage breast cancer. These assays were designed to be more specific than conventional clinico-pathologic parameters in...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2013
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| In: |
Geburtshilfe und Frauenheilkunde
Year: 2013, Jahrgang: 73, Heft: 9, Pages: 932-940 |
| ISSN: | 1438-8804 |
| DOI: | 10.1055/s-0033-1350831 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1055/s-0033-1350831 Verlag, kostenfrei, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1350831 |
| Verfasserangaben: | P. Sinn, S. Aulmann, R. Wirtz, S. Schott, F. Marmé, Z. Varga, A. Lebeau, H. Kreipe, A. Schneeweiss |
| Zusammenfassung: | <p>Gene signatures which are based on multigene profiling assays have been developed for the purpose to better define the prognosis and prediction of therapy results in early-stage breast cancer. These assays were designed to be more specific than conventional clinico-pathologic parameters in the selection of patients for (neo-)adjuvant treatment and in effect help to avoid unnecessary cytotoxic treatment. In this review we describe molecular risk scores, for which tests are commercially available (PAM50®, MammaTyper®, MammaPrint®, Oncotype DX®, Endopredict®, Genomic Grade Index®) and IHC risk scores (Mammostrat® and IHC4), and discuss the current evidence of their clinical use.</p> |
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| Beschreibung: | Publikationsdatum: 11. Oktober 2013 (online) Gesehen am 03.02.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 1438-8804 |
| DOI: | 10.1055/s-0033-1350831 |