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Multigene assays for classification, prognosis, and prediction in breast cancer: a critical review on the background and clinical utility = Multigenassays zur Beurteilung der Klassifikation, Prognose und Prädiktion beim Mammakarzinom : ein kritischer Review zum Hintergrund und klinischen Nutzen

<p>Gene signatures which are based on multigene profiling assays have been developed for the purpose to better define the prognosis and prediction of therapy results in early-stage breast cancer. These assays were designed to be more specific than conventional clinico-pathologic parameters in...

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Main Authors: Sinn, Peter (Author) , Aulmann, Sebastian (Author) , Wirtz, R. (Author) , Schott, Sarah (Author) , Marmé, Frederik (Author) , Varga, Z. (Author) , Lebeau, A. (Author) , Kreipe, H. (Author) , Schneeweiss, Andreas (Author)
Format: Article (Journal)
Language:English
Published: 2013
In: Geburtshilfe und Frauenheilkunde
Year: 2013, Volume: 73, Issue: 9, Pages: 932-940
ISSN:1438-8804
DOI:10.1055/s-0033-1350831
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1055/s-0033-1350831
Verlag, kostenfrei, Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0033-1350831
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Author Notes:P. Sinn, S. Aulmann, R. Wirtz, S. Schott, F. Marmé, Z. Varga, A. Lebeau, H. Kreipe, A. Schneeweiss
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Summary:<p>Gene signatures which are based on multigene profiling assays have been developed for the purpose to better define the prognosis and prediction of therapy results in early-stage breast cancer. These assays were designed to be more specific than conventional clinico-pathologic parameters in the selection of patients for (neo-)adjuvant treatment and in effect help to avoid unnecessary cytotoxic treatment. In this review we describe molecular risk scores, for which tests are commercially available (PAM50®, MammaTyper®, MammaPrint®, Oncotype DX®, Endopredict®, Genomic Grade Index®) and IHC risk scores (Mammostrat® and IHC4), and discuss the current evidence of their clinical use.</p>
Item Description:Publikationsdatum: 11. Oktober 2013 (online)
Gesehen am 03.02.2022
Physical Description:Online Resource
ISSN:1438-8804
DOI:10.1055/s-0033-1350831

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