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The extent of HLA-DR expression on HLA-DR+ Tregs allows the identification of patients with clinically relevant borderline rejection

Regulatory T cells (Tregs) were shown to be involved into the pathogenesis of acute rejection after transplantation. The suppressive activity of the total regulatory T cell pool depends on its percentage of highly suppressive HLA-DR+-Treg cells. Therefore, both the suppressive activity of the total...

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Main Authors: Schaier, Matthias (Author) , Seissler, Nicole (Author) , Becker, Luis Eduardo (Author) , Schäfer, Sebastian Markus (Author) , Schmitt, Edgar (Author) , Meuer, Stefan (Author) , Hug, Friederike (Author) , Sommerer, Claudia (Author) , Waldherr, Rüdiger (Author) , Zeier, Martin (Author) , Steinborn-Kröhl, Andrea (Author)
Format: Article (Journal)
Language:English
Published: 2 January 2013
In: Transplant international
Year: 2013, Volume: 26, Issue: 3, Pages: 290-299
ISSN:1432-2277
DOI:10.1111/tri.12032
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/tri.12032
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tri.12032
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Author Notes:Matthias Schaier, Nicole Seissler, Luis Eduardo Becker, Sebastian Markus Schaefer, Edgar Schmitt, Stefan Meuer, Friederike Hug, Claudia Sommerer, Rüdiger Waldherr, Martin Zeier and Andrea Steinborn
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Summary:Regulatory T cells (Tregs) were shown to be involved into the pathogenesis of acute rejection after transplantation. The suppressive activity of the total regulatory T cell pool depends on its percentage of highly suppressive HLA-DR+-Treg cells. Therefore, both the suppressive activity of the total Treg pool and the extent of HLA-DR expression of HLA-DR+-Tregs (MFI HLA-DR) were estimated in non transplanted volunteers, patients with end-stage renal failure (ESRF), healthy renal transplant patients with suspicion on rejection, due to sole histological Bord-R or sole acute renal failure (ARF), and patients with clinically relevant borderline rejection (Bord-R and ARF). Compared to patients with only Bord-R or only ARF, the suppressive activity of the total Treg cell pool was exclusively reduced in patients with clinically relevant Bord-R. In parallel, the HLA-DR MFI of the DR+-Treg subset was significantly decreased in these patients, due to a significantly lower proportion of DRhigh+-Tregs, which were shown to have the highest suppressive capacity within the total Treg pool. Our findings clearly demonstrate that the determination of the HLA-DR MFI of the HLA-DR+-Treg subset allows a highly sensitive, specific and non-invasive discrimination between patients with clinically relevant Bord-R (Bord and ARF) and patients with subclinical rejection or other causes of transplant failure.
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ISSN:1432-2277
DOI:10.1111/tri.12032

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