The extent of HLA-DR expression on HLA-DR+ Tregs allows the identification of patients with clinically relevant borderline rejection
Regulatory T cells (Tregs) were shown to be involved into the pathogenesis of acute rejection after transplantation. The suppressive activity of the total regulatory T cell pool depends on its percentage of highly suppressive HLA-DR+-Treg cells. Therefore, both the suppressive activity of the total...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2 January 2013
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| In: |
Transplant international
Year: 2013, Volume: 26, Issue: 3, Pages: 290-299 |
| ISSN: | 1432-2277 |
| DOI: | 10.1111/tri.12032 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/tri.12032 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/tri.12032 
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| Author Notes: | Matthias Schaier, Nicole Seissler, Luis Eduardo Becker, Sebastian Markus Schaefer, Edgar Schmitt, Stefan Meuer, Friederike Hug, Claudia Sommerer, Rüdiger Waldherr, Martin Zeier and Andrea Steinborn |
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| 520 | |a Regulatory T cells (Tregs) were shown to be involved into the pathogenesis of acute rejection after transplantation. The suppressive activity of the total regulatory T cell pool depends on its percentage of highly suppressive HLA-DR+-Treg cells. Therefore, both the suppressive activity of the total Treg pool and the extent of HLA-DR expression of HLA-DR+-Tregs (MFI HLA-DR) were estimated in non transplanted volunteers, patients with end-stage renal failure (ESRF), healthy renal transplant patients with suspicion on rejection, due to sole histological Bord-R or sole acute renal failure (ARF), and patients with clinically relevant borderline rejection (Bord-R and ARF). Compared to patients with only Bord-R or only ARF, the suppressive activity of the total Treg cell pool was exclusively reduced in patients with clinically relevant Bord-R. In parallel, the HLA-DR MFI of the DR+-Treg subset was significantly decreased in these patients, due to a significantly lower proportion of DRhigh+-Tregs, which were shown to have the highest suppressive capacity within the total Treg pool. Our findings clearly demonstrate that the determination of the HLA-DR MFI of the HLA-DR+-Treg subset allows a highly sensitive, specific and non-invasive discrimination between patients with clinically relevant Bord-R (Bord and ARF) and patients with subclinical rejection or other causes of transplant failure. | ||
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