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Regulatory modules mediating the complex neural expression patterns of the homeobrain gene during Drosophila brain development

The homeobox gene homeobrain (hbn) is located in the 57B region together with two other homeobox genes, Drosophila Retinal homeobox (DRx) and orthopedia (otp). All three genes encode transcription factors with important functions in brain development. Hbn mutants are embryonic lethal and characteriz...

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Main Authors: Hildebrandt, Kirsten (Author) , Kolb, Dieter (Author) , Klöppel, Christine (Author) , Kaspar, Petra (Author) , Wittling, Fabienne (Author) , Hartwig, Olga (Author) , Federspiel, Jannic (Author) , Findji, India (Author) , Walldorf, Uwe (Author)
Format: Article (Journal)
Language:English
Published: 05 January 2022
In: Hereditas
Year: 2022, Volume: 159, Issue: 1, Pages: 1-23
ISSN:1601-5223
DOI:10.1186/s41065-021-00218-5
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1186/s41065-021-00218-5
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Author Notes:Kirsten Hildebrandt, Dieter Kolb, Christine Klöppel, Petra Kaspar, Fabienne Wittling, Olga Hartwig, Jannic Federspiel, India Findji, Uwe Walldorf
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Summary:The homeobox gene homeobrain (hbn) is located in the 57B region together with two other homeobox genes, Drosophila Retinal homeobox (DRx) and orthopedia (otp). All three genes encode transcription factors with important functions in brain development. Hbn mutants are embryonic lethal and characterized by a reduction in the anterior protocerebrum, including the mushroom bodies, and a loss of the supraoesophageal brain commissure.
Item Description:Gesehen am 03.02.2022
Physical Description:Online Resource
ISSN:1601-5223
DOI:10.1186/s41065-021-00218-5

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