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Circulating interleukin-4 is associated with a systemic T cell response against tumor-associated antigens in treatment-naïve patients with resectable non-small-cell lung cancer

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Spontaneous T cell responses to tumor-associated antigens (TAs) in the peripheral blood of patients with non-small-cell lung cancer (NSCLC) may be relevant for postoperative survival. However, the conditions underlying these T cell responses remain unclear. We quantified the levels of 27 cytokines i...

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Main Authors: Safi, Seyer (Author) , Yamauchi, Yoshikane (Author) , Hoffmann, Hans (Author) , Weichert, Wilko (Author) , Jost, Philipp J. (Author) , Winter, Hauke (Author) , Muley, Thomas (Author) , Beckhove, Philipp (Author)
Format: Article (Journal)
Language:English
Published: 24 November 2020
In: Cancers
Year: 2020, Volume: 12, Issue: 12, Pages: 1-20
ISSN:2072-6694
DOI:10.3390/cancers12123496
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/cancers12123496
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6694/12/12/3496
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Author Notes:Seyer Safi, Yoshikane Yamauchi, Hans Hoffmann, Wilko Weichert, Philipp J. Jost, Hauke Winter, Thomas Muley and Philipp Beckhove
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Summary:Spontaneous T cell responses to tumor-associated antigens (TAs) in the peripheral blood of patients with non-small-cell lung cancer (NSCLC) may be relevant for postoperative survival. However, the conditions underlying these T cell responses remain unclear. We quantified the levels of 27 cytokines in the peripheral blood and tumor tissues from treatment-naïve patients with NSCLC (n = 36) and analyzed associations between local and systemic cytokine profiles and both TA-specific T cell responses and clinical parameters. We defined T cell responders as patients with circulating T cells that were reactive to TAs and T cell nonresponders as patients without detectable TA-specific T cells. TA-specific T cell responses were correlated with serum cytokine levels, particularly the levels of interleukin(IL)-4 and granulocyte colony-stimulating factor (G-CSF), but poorly correlated with the cytokine levels in tumor tissues. Nonresponders showed significantly higher serum IL-4 levels than responders (p = 0.03); the predicted probability of being a responder was higher for individuals with low serum IL-4 levels. In multivariable Cox regression analyses, in addition to IL-4 (hazard ratio (HR) 2.8 (95% confidence interval (CI): 0.78-9.9); p = 0.116), the age-adjusted IL-8 level (HR 3.9 (95% CI: 1.05-14.5); p = 0.042) predicted tumor recurrence. However, this study included data for many cytokines without adjustment for multiple testing; thus, the observed differences in IL-4 or IL-8 levels might be incidental findings. Therefore, additional studies are necessary to confirm these results.
Item Description:Gesehen am 03.03.2022
Physical Description:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers12123496

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