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No impact of KIR-ligand mismatch on allograft outcome in HLA-compatible kidney transplantation

Natural killer (NK) cell function can be modulated by the killer cell immunoglobulin-like receptors (KIR) which interact with human leukocyte antigen (HLA) class I molecules on target cells. KIR-ligand mismatching has recently been shown by van Bergen et al. (American Journal of Transplantation 2011...

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Main Authors: Tran, Thuong Hien (Author) , Unterrainer, Christian (Author) , Fiedler, Gerd (Author) , Döhler, Bernd (Author) , Scherer, Sabine (Author) , Ruhenstroth, Andrea (Author) , Adamek, Martina Maria (Author) , Middleton, D. (Author) , Opelz, Gerhard (Author)
Format: Article (Journal)
Language:English
Published: 07 February 2013
In: American journal of transplantation
Year: 2013, Volume: 13, Issue: 4, Pages: 1063-1068
ISSN:1600-6143
DOI:10.1111/ajt.12134
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/ajt.12134
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/ajt.12134
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Author Notes:T.H. Tran, C. Unterrainer, G. Fiedler, B. Döhler, S. Scherer, A. Ruhenstroth, M. Adamek, D. Middleton and G. Opelz
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Summary:Natural killer (NK) cell function can be modulated by the killer cell immunoglobulin-like receptors (KIR) which interact with human leukocyte antigen (HLA) class I molecules on target cells. KIR-ligand mismatching has recently been shown by van Bergen et al. (American Journal of Transplantation 2011; 11(9): 1959-1964) to be a significant risk factor for long-term graft loss in HLA-A, -B and -DR compatible kidney transplants. To verify this potentially important finding, we performed genotyping of 608 deceased-donor kidney graft recipients and their HLA-A, -B and -DR compatible donors for KIR and HLA, using samples and clinical data provided by the Collaborative Transplant Study. Graft survival of KIR-ligand-matched and -mismatched transplants was compared. We found no impact of KIR-ligand mismatching on 10-year graft survival in HLA-A, -B, -DR compatible kidney transplants. Further analysis did not reveal a significant effect of recipient activating/inhibitory KIR or KIR genotypes on graft survival. Our data do not support the concept that KIR-HLA matching might serve as a tool to improve long-term renal allograft survival.
Item Description:Gesehen am 10.02.2022
Physical Description:Online Resource
ISSN:1600-6143
DOI:10.1111/ajt.12134

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