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Concomitant chronic lymphocytic leukemia and multiple myeloma: proof of common clonal origin

We describe a patient with concomitant B-cell chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). CLL- and MM-cell were separated by preparative flourescence-activated cell sorting (FACS). DNA sequence analysis of the complementarity-determinining region III (CDR III) of the immunoglobulin...

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Bibliographic Details
Main Authors: Sucker, Christoph (Author) , Krämer, Alwin (Author) , Moos, Marion (Author) , Goldschmidt, Hartmut (Author)
Format: Article (Journal)
Language:English
Published: June 2004
In: The Chinese-german journal of clinical oncology
Year: 2004, Volume: 3, Issue: 2, Pages: 81-84
ISSN:1613-9089
DOI:10.1007/s10330-004-0264-6
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s10330-004-0264-6
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Author Notes:Christoph Sucker, Alwin Krämer, Marion Moos& Hartmut Goldschmidt
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Summary:We describe a patient with concomitant B-cell chronic lymphocytic leukemia (CLL) and multiple myeloma (MM). CLL- and MM-cell were separated by preparative flourescence-activated cell sorting (FACS). DNA sequence analysis of the complementarity-determinining region III (CDR III) of the immunoglobulin heavy chain genes showed identical gene rearrangements in the CLL- and the MM-cell population. Our findings prove a common clonal tumor origin of both B-cell diseases in this patient.
Item Description:Gesehen am 11.02.2022
Physical Description:Online Resource
ISSN:1613-9089
DOI:10.1007/s10330-004-0264-6

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