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Allogeneic immunotherapy for relapsed multiple myeloma: role of matched unrelated donors

Existence of a graft-versus-myeloma effect has been well documented by responses to donor lymphocyte infusions and longterm survival after allogeneic bone marrow transplantation. The development of non-myeloablative conditioning regimens allows utilization of allogeneic effects in patients usually n...

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Bibliographic Details
Main Authors: Görner, Martin (Author) , Höpfner, Sabine (Author) , Goldschmidt, Hartmut (Author) , Ho, Anthony Dick (Author)
Format: Article (Journal)
Language:English
Published: June 2002
In: The Chinese-german journal of clinical oncology
Year: 2002, Volume: 1, Issue: 2, Pages: 72-74
ISSN:1613-9089
DOI:10.1007/BF02851737
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/BF02851737
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Author Notes:M. Görner, S. Höpfner, H. Goldschmidt & A.D. Ho
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Summary:Existence of a graft-versus-myeloma effect has been well documented by responses to donor lymphocyte infusions and longterm survival after allogeneic bone marrow transplantation. The development of non-myeloablative conditioning regimens allows utilization of allogeneic effects in patients usually not suitable for myeloablative allogeneic transplantation, such as older and heavily pretreated patients. In a small series of 11 patients with multiple myeloma relapsing after autologous transplantation, we show that conditioning with low-dose total body irradiation in combination with fludarabine allows stable engraftment after matched unrelated donor transplantation and is tolerated with acceptable transplant-related morbidity and mortality. With a short median follow-up of 225 days, disease control was achieved only for patients responding to conventional treatment prior to allografting. Future studies with longer follow-up have to define the role of non-myeloablative allogeneic transplantation from unrelated donors as consolidation for patients responding to salvage therapy.
Item Description:Gesehen am 11.02.2022
Physical Description:Online Resource
ISSN:1613-9089
DOI:10.1007/BF02851737

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