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SOX2 in development and cancer biology

The transcription factor SOX2 is essential for embryonic development and plays a crucial role in maintaining the stemness of embryonic cells and various adult stem cell populations. On the other hand, dysregulation of SOX2 expression is associated with a multitude of cancer types and it has been sho...

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Main Authors: Novak, Daniel (Author) , Hüser, Laura (Author) , Elton, Jonathan J. (Author) , Umansky, Viktor (Author) , Altevogt, Peter (Author) , Utikal, Jochen (Author)
Format: Article (Journal)
Language:English
Published: December 2020
In: Seminars in cancer biology
Year: 2020, Volume: 67, Issue: 1, Pages: 74-82
ISSN:1096-3650
DOI:10.1016/j.semcancer.2019.08.007
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.semcancer.2019.08.007
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1044579X18301858
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Author Notes:Daniel Novak, Laura Hüser, Jonathan J. Elton, Viktor Umansky, Peter Altevogt, Jochen Utikal
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Summary:The transcription factor SOX2 is essential for embryonic development and plays a crucial role in maintaining the stemness of embryonic cells and various adult stem cell populations. On the other hand, dysregulation of SOX2 expression is associated with a multitude of cancer types and it has been shown that SOX2 positively affects cancer cell traits such as the capacity to proliferate, migrate, invade and metastasize. Moreover, there is growing evidence that SOX2 mediates resistance towards established cancer therapies and that it is expressed in cancer stem cells. These findings indicate that studying the role of SOX2 in the context of cancer progression could lead to the development of new therapeutic options. In this review, the current knowledge about the role of SOX2 in development, maintenance of stemness, cancer progression and the resistance towards cancer therapies is summarized.
Item Description:Available online 11 August 2019
Gesehen am 17.02.2022
Physical Description:Online Resource
ISSN:1096-3650
DOI:10.1016/j.semcancer.2019.08.007

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