On track to tackle dengue: History and future of NS4B ligands
A recent publication in Nature (Kaptein et al., 2021) reports a highly potent antiviral compound against dengue with promising efficacy in mice. Here, we track the history of this compound class, its pharmacology, and its chemistry, with insights into its potential as orally available drugs to preve...
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| Main Authors: | , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
8 December 2021
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| In: |
Cell host and microbe
Year: 2021, Volume: 29, Issue: 12, Pages: 1735-1737 |
| ISSN: | 1934-6069 |
| DOI: | 10.1016/j.chom.2021.11.010 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.chom.2021.11.010 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1931312821005163 
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| Author Notes: | Mira A.M. Behnam, Christian D. Klein |
| Summary: | A recent publication in Nature (Kaptein et al., 2021) reports a highly potent antiviral compound against dengue with promising efficacy in mice. Here, we track the history of this compound class, its pharmacology, and its chemistry, with insights into its potential as orally available drugs to prevent and treat dengue. |
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| Item Description: | Gesehen am 15.02.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1934-6069 |
| DOI: | 10.1016/j.chom.2021.11.010 |