Assembly of infectious hepatitis C virus particles
A hallmark of the hepatitis C virus (HCV) replication cycle is its tight link with host cell lipid synthesis. This is best illustrated by the peculiar pathway used for the assembly of infectious HCV particles. Research in the past few years has shown that formation of HC-virions is closely connected...
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| Main Authors: | , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2011
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| In: |
Trends in microbiology
Year: 2011, Volume: 19, Issue: 2, Pages: 95-103 |
| ISSN: | 1878-4380 |
| DOI: | 10.1016/j.tim.2010.11.005 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.tim.2010.11.005 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0966842X1000199X 
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| Author Notes: | Ralf Bartenschlager, Francois Penin, Volker Lohmann and Patrice André |
| Summary: | A hallmark of the hepatitis C virus (HCV) replication cycle is its tight link with host cell lipid synthesis. This is best illustrated by the peculiar pathway used for the assembly of infectious HCV particles. Research in the past few years has shown that formation of HC-virions is closely connected to lipid droplets that could serve as an assembly platform. Moreover, HCV particle production appears to be strictly linked to very-low-density lipoproteins. In this review, we focus on new insights into the molecular aspects of the architecture and assembly of this unique type of virus particle. |
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| Item Description: | Gesehen am 17.02.2022 First published: 14 December 2010 |
| Physical Description: | Online Resource |
| ISSN: | 1878-4380 |
| DOI: | 10.1016/j.tim.2010.11.005 |