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DNAm-based signatures of accelerated aging and mortality in blood are associated with low renal function

The difference between an individual's chronological and DNA methylation predicted age (DNAmAge), termed DNAmAge acceleration (DNAmAA), can capture life-long environmental exposures and age-related physiological changes reflected in methylation status. Several studies have linked DNAmAA to morb...

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Main Authors: Matías-García, Pamela R. (Author) , Ward-Caviness, Cavin K. (Author) , Raffield, Laura M. (Author) , Gao, Xu (Author) , Zhang, Yan (Author) , Wilson, Rory (Author) , Gao, Xin (Author) , Nano, Jana (Author) , Bostom, Andrew (Author) , Colicino, Elena (Author) , Correa, Adolfo (Author) , Coull, Brent (Author) , Eaton, Charles (Author) , Hou, Lifang (Author) , Just, Allan C. (Author) , Kunze, Sonja (Author) , Lange, Leslie (Author) , Lange, Ethan (Author) , Lin, Xihong (Author) , Liu, Simin (Author) , Nwanaji-Enwerem, Jamaji C. (Author) , Reiner, Alex (Author) , Shen, Jincheng (Author) , Schöttker, Ben (Author) , Vokonas, Pantel (Author) , Zheng, Yinan (Author) , Young, Bessie (Author) , Schwartz, Joel (Author) , Horvath, Steve (Author) , Lu, Ake (Author) , Whitsel, Eric A. (Author) , Koenig, Wolfgang (Author) , Adamski, Jerzy (Author) , Winkelmann, Juliane (Author) , Brenner, Hermann (Author) , Baccarelli, Andrea A. (Author) , Gieger, Christian (Author) , Peters, Annette (Author) , Franceschini, Nora (Author) , Waldenberger, Melanie (Author)
Format: Article (Journal)
Language:English
Published: 02 June 2021
In: Clinical epigenetics
Year: 2021, Volume: 13, Issue: 1, Pages: 1-16
ISSN:1868-7083
DOI:10.1186/s13148-021-01082-w
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/s13148-021-01082-w
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Author Notes:Pamela R. Matías-García, Cavin K. Ward-Caviness, Laura M. Raffield, Xu Gao, Yan Zhang, Rory Wilson, Xīn Gào, Jana Nano, Andrew Bostom, Elena Colicino, Adolfo Correa, Brent Coull, Charles Eaton, Lifang Hou, Allan C. Just, Sonja Kunze, Leslie Lange, Ethan Lange, Xihong Lin, Simin Liu, Jamaji C. Nwanaji-Enwerem, Alex Reiner, Jincheng Shen, Ben Schöttker, Pantel Vokonas, Yinan Zheng, Bessie Young, Joel Schwartz, Steve Horvath, Ake Lu, Eric A. Whitsel, Wolfgang Koenig, Jerzy Adamski, Juliane Winkelmann, Hermann Brenner, Andrea A. Baccarelli, Christian Gieger, Annette Peters, Nora Franceschini and Melanie Waldenberger
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Summary:The difference between an individual's chronological and DNA methylation predicted age (DNAmAge), termed DNAmAge acceleration (DNAmAA), can capture life-long environmental exposures and age-related physiological changes reflected in methylation status. Several studies have linked DNAmAA to morbidity and mortality, yet its relationship with kidney function has not been assessed. We evaluated the associations between seven DNAm aging and lifespan predictors (as well as GrimAge components) and five kidney traits (estimated glomerular filtration rate [eGFR], urine albumin-to-creatinine ratio [uACR], serum urate, microalbuminuria and chronic kidney disease [CKD]) in up to 9688 European, African American and Hispanic/Latino individuals from seven population-based studies.
Item Description:Gesehen am 18.02.2022
Physical Description:Online Resource
ISSN:1868-7083
DOI:10.1186/s13148-021-01082-w

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