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Hyperspectral imaging for the evaluation of microcirculatory tissue oxygenation and perfusion quality in haemorrhagic shock: a porcine study

Background: The ultimate goal of haemodynamic therapy is to improve microcirculatory tissue and organ perfusion. Hyperspectral imaging (HSI) has the potential to enable noninvasive microcirculatory monitoring at bedside. Methods: HSI (Tivita® Tissue System) measurements of tissue oxygenation, haemog...

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Hauptverfasser: Dietrich, Maximilian (VerfasserIn) , Özdemir, Berkin (VerfasserIn) , Gruneberg, Daniel (VerfasserIn) , Petersen, Clara (VerfasserIn) , Studier-Fischer, Alexander (VerfasserIn) , Forst, Maik von der (VerfasserIn) , Schmitt, Felix (VerfasserIn) , Fiedler-Kalenka, Mascha (VerfasserIn) , Nickel, Felix (VerfasserIn) , Müller, Beat P. (VerfasserIn) , Brenner, Thorsten (VerfasserIn) , Weigand, Markus A. (VerfasserIn) , Uhle, Florian (VerfasserIn) , Schmidt, Karsten (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 3 December 2021
In: Biomedicines
Year: 2021, Jahrgang: 9, Heft: 12, Pages: 1-14
ISSN:2227-9059
DOI:10.3390/biomedicines9121829
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/biomedicines9121829
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2227-9059/9/12/1829
Volltext
Verfasserangaben:Maximilian Dietrich, Berkin Özdemir, Daniel Gruneberg, Clara Petersen, Alexander Studier-Fischer, Maik von der Forst, Felix C.F. Schmitt, Mascha O. Fiedler, Felix Nickel, Beat Peter Müller-Stich, Thorsten Brenner, Markus A. Weigand, Florian Uhle, Karsten Schmidt
Beschreibung
Zusammenfassung:Background: The ultimate goal of haemodynamic therapy is to improve microcirculatory tissue and organ perfusion. Hyperspectral imaging (HSI) has the potential to enable noninvasive microcirculatory monitoring at bedside. Methods: HSI (Tivita® Tissue System) measurements of tissue oxygenation, haemoglobin, and water content in the skin (ear) and kidney were evaluated in a double-hit porcine model of major abdominal surgery and haemorrhagic shock. Animals of the control group (n = 7) did not receive any resuscitation regime. The interventional groups were treated exclusively with either crystalloid (n = 8) or continuous norepinephrine infusion (n = 7). Results: Haemorrhagic shock led to a drop in tissue oxygenation parameters in all groups. These correlated with established indirect markers of tissue oxygenation. Fluid therapy restored tissue oxygenation parameters. Skin and kidney measurements correlated well. High dose norepinephrine therapy deteriorated tissue oxygenation. Tissue water content increased both in the skin and the kidney in response to fluid therapy. Conclusions: HSI detected dynamic changes in tissue oxygenation and perfusion quality during shock and was able to indicate resuscitation effectivity. The observed correlation between HSI skin and kidney measurements may offer an estimation of organ oxygenation impairment from skin monitoring. HSI microcirculatory monitoring could open up new opportunities for the guidance of haemodynamic management.
Beschreibung:Gesehen am 21.02.2022
Beschreibung:Online Resource
ISSN:2227-9059
DOI:10.3390/biomedicines9121829

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