Cover Image

Targeted blood brain barrier opening with focused ultrasound induces focal macrophage/microglial activation in experimental autoimmune encephalomyelitis

Experimental autoimmune encephalomyelitis (EAE) is a model of multiple sclerosis (MS). EAE reflects important histopathological hallmarks, dissemination, and diversity of the disease, but has only moderate reproducibility of clinical and histopathological features. Focal lesions are less frequently...

Full description

Saved in:
Bibliographic Details
Main Authors: Schregel, Katharina (Author) , Baufeld, Caroline (Author) , Palotai, Miklos (Author) , Meroni, Roberta (Author) , Fiorina, Paolo (Author) , Wuerfel, Jens (Author) , Sinkus, Ralph (Author) , Zhang, Yong-Zhi (Author) , McDannold, Nathan (Author) , White, P. Jason (Author) , Guttmann, Charles R. G. (Author)
Format: Article (Journal)
Language:English
Published: 12 May 2021
In: Frontiers in neuroscience
Year: 2021, Volume: 15, Pages: 1-15
ISSN:1662-453X
Online Access:Verlag, lizenzpflichtig, Volltext: https://www.frontiersin.org/article/10.3389/fnins.2021.665722
Get full text
Author Notes:Katharina Schregel, Caroline Baufeld, Miklos Palotai, Roberta Meroni, Paolo Fiorina, Jens Wuerfel, Ralph Sinkus, Yong-Zhi Zhang, Nathan McDannold, P. Jason White and Charles R.G. Guttmann
Description
Summary:Experimental autoimmune encephalomyelitis (EAE) is a model of multiple sclerosis (MS). EAE reflects important histopathological hallmarks, dissemination, and diversity of the disease, but has only moderate reproducibility of clinical and histopathological features. Focal lesions are less frequently observed in EAE than in MS, and can neither be constrained to specific locations nor timed to occur at a pre-specified moment. This renders difficult any experimental assessment of the pathogenesis of lesion evolution, including its inflammatory, degenerative (demyelination and axonal degeneration), and reparatory (remyelination, axonal sprouting, gliosis) component processes. We sought to develop a controlled model of inflammatory, focal brain lesions in EAE using focused ultrasound (FUS). We hypothesized that FUS induced focal blood brain barrier disruption (BBBD) will increase the likelihood of transmigration of effector cells and subsequent lesion occurrence at the sonicated location. Lesion development was monitored with conventional magnetic resonance imaging (MRI) as well as with magnetic resonance elastography (MRE) and further analyzed by histopathological means ...
Item Description:Gesehen am 22.02.2022
Physical Description:Online Resource
ISSN:1662-453X

Similar Items