Cover Image

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms

A nef gene is present in all primate lentiviral genomes and is important for high viral loads and progression to AIDS in human or experimental macaque hosts of HIV or SIV, respectively. In these hosts, infection of the thymus results in a decreased output of naive T cells that may contribute to the...

Full description

Saved in:
Bibliographic Details
Main Authors: Van Nuffel, Anouk (Author) , Ariën, Kevin K. (Author) , Stove, Veronique (Author) , Schindler, Michael (Author) , O’Neill, Eduardo (Author) , Schmökel, Jan (Author) , Van de Walle, Inge (Author) , Naessens, Evelien (Author) , Vanderstraeten, Hanne (Author) , Van Landeghem, Kathleen (Author) , Taghon, Tom (Author) , Pulkkinen, Kati (Author) , Saksela, Kalle (Author) , Garcia, J. Victor (Author) , Fackler, Oliver Till (Author) , Kirchhoff, Frank (Author) , Verhasselt, Bruno (Author)
Format: Article (Journal)
Language:English
Published: 15 November 2013
In: Retrovirology
Year: 2013, Volume: 10, Pages: 1-13
ISSN:1742-4690
DOI:10.1186/1742-4690-10-137
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1186/1742-4690-10-137
Get full text
Author Notes:Anouk Van Nuffel, Kevin K. Ariën, Veronique Stove, Michael Schindler, Eduardo O’Neill, Jan Schmökel, Inge Van de Walle, Evelien Naessens, Hanne Vanderstraeten, Kathleen Van Landeghem, Tom Taghon, Kati Pulkkinen, Kalle Saksela, J. Victor Garcia, Oliver T. Fackler, Frank Kirchhoff and Bruno Verhasselt
Description
Summary:A nef gene is present in all primate lentiviral genomes and is important for high viral loads and progression to AIDS in human or experimental macaque hosts of HIV or SIV, respectively. In these hosts, infection of the thymus results in a decreased output of naive T cells that may contribute to the development of immunodeficiency. We have previously shown that HIV-1 subtype B Nef proteins can block human T-cell development. However, the underlying mechanism(s) and the conservation of this Nef function between different groups of HIV and SIV remained to be determined.
Item Description:Gesehen am 24.02.2022
Physical Description:Online Resource
ISSN:1742-4690
DOI:10.1186/1742-4690-10-137

Similar Items