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Duplication of chromosome arms 9q and 11q: Evidence for a novel, 14q32 translocation-independent pathogenetic pathway in multiple myeloma

14q32 translocations [t(14q)] represent critical but not universal events in multiple myeloma (MM). Gains of chromosome arms 1q, 9q, and 11q (+1q, +9q, and +11q) have recently been identified as frequent aberrations in this disease, but their pathogenetic significance remains unclear. We studied a s...

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Hauptverfasser: Liebisch, Peter (VerfasserIn) , Scheck, Daniel (VerfasserIn) , Erné, Seiichi Alvise (VerfasserIn) , Wellmann, Alexander (VerfasserIn) , Wendl, Christiane (VerfasserIn) , Janczik, Sibylle (VerfasserIn) , Kolmus, Sonja (VerfasserIn) , Kröber, Alexander (VerfasserIn) , Einsele, Hermann (VerfasserIn) , Straka, Christian (VerfasserIn) , Goldschmidt, Hartmut (VerfasserIn) , Benner, Axel (VerfasserIn) , Stilgenbauer, Stephan (VerfasserIn) , Döhner, Hartmut (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: [January 2005]
In: Genes, chromosomes & cancer
Year: 2005, Jahrgang: 42, Heft: 1, Pages: 78-81
ISSN:1098-2264
DOI:10.1002/gcc.20098
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/gcc.20098
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/gcc.20098
Volltext
Verfasserangaben:Peter Liebisch, Daniel Scheck, Seiichi Alvise Erné, Alexander Wellmann, Christiane Wendl, Sibylle Janczik, Sonja Kolmus, Alexander Kröber, Hermann Einsele, Christian Straka, Hartmut Goldschmidt, Axel Benner, Stephan Stilgenbauer, Hartmut Döhner
Beschreibung
Zusammenfassung:14q32 translocations [t(14q)] represent critical but not universal events in multiple myeloma (MM). Gains of chromosome arms 1q, 9q, and 11q (+1q, +9q, and +11q) have recently been identified as frequent aberrations in this disease, but their pathogenetic significance remains unclear. We studied a series of 108 MM patients using fluorescence in situ hybridization and DNA probes mapping to chromosome bands 1q21, 9q34, 11q25, 13q14, and 14q32. Three subsets of tumors were defined: (1) MM+/+ (detection of +9q and +11q; 43.5% of cases), (2) MM+/− (+9q or +11q; 21.3%), and (3) MM−/− (neither +9q nor +11q; 35.2%). The incidence of t(14q) was significantly different in these subgroups: 23% in MM+/+, 56% in MM+/−, and 89% in MM−/−. Deletion of 13q (13q−) also was significantly less frequent in MM+/+ (23%) than in MM+/− and MM−/− (36% and 63%, respectively). The nonrandom distribution of chromosomal aberrations in the present series of MM tumors points to a novel, 14q32 translocation-independent pathogenetic pathway in plasma cell neoplasms. © 2005 Wiley-Liss, Inc.
Beschreibung:Published online 23 September 2004 in Wiley InterScience
Gesehen am 25.02.2022
Beschreibung:Online Resource
ISSN:1098-2264
DOI:10.1002/gcc.20098

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