Duplication of chromosome arms 9q and 11q: Evidence for a novel, 14q32 translocation-independent pathogenetic pathway in multiple myeloma
14q32 translocations [t(14q)] represent critical but not universal events in multiple myeloma (MM). Gains of chromosome arms 1q, 9q, and 11q (+1q, +9q, and +11q) have recently been identified as frequent aberrations in this disease, but their pathogenetic significance remains unclear. We studied a s...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
[January 2005]
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| In: |
Genes, chromosomes & cancer
Year: 2005, Volume: 42, Issue: 1, Pages: 78-81 |
| ISSN: | 1098-2264 |
| DOI: | 10.1002/gcc.20098 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/gcc.20098 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/gcc.20098 
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| Author Notes: | Peter Liebisch, Daniel Scheck, Seiichi Alvise Erné, Alexander Wellmann, Christiane Wendl, Sibylle Janczik, Sonja Kolmus, Alexander Kröber, Hermann Einsele, Christian Straka, Hartmut Goldschmidt, Axel Benner, Stephan Stilgenbauer, Hartmut Döhner |
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| 245 | 1 | 0 | |a Duplication of chromosome arms 9q and 11q |b Evidence for a novel, 14q32 translocation-independent pathogenetic pathway in multiple myeloma |c Peter Liebisch, Daniel Scheck, Seiichi Alvise Erné, Alexander Wellmann, Christiane Wendl, Sibylle Janczik, Sonja Kolmus, Alexander Kröber, Hermann Einsele, Christian Straka, Hartmut Goldschmidt, Axel Benner, Stephan Stilgenbauer, Hartmut Döhner |
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| 520 | |a 14q32 translocations [t(14q)] represent critical but not universal events in multiple myeloma (MM). Gains of chromosome arms 1q, 9q, and 11q (+1q, +9q, and +11q) have recently been identified as frequent aberrations in this disease, but their pathogenetic significance remains unclear. We studied a series of 108 MM patients using fluorescence in situ hybridization and DNA probes mapping to chromosome bands 1q21, 9q34, 11q25, 13q14, and 14q32. Three subsets of tumors were defined: (1) MM+/+ (detection of +9q and +11q; 43.5% of cases), (2) MM+/− (+9q or +11q; 21.3%), and (3) MM−/− (neither +9q nor +11q; 35.2%). The incidence of t(14q) was significantly different in these subgroups: 23% in MM+/+, 56% in MM+/−, and 89% in MM−/−. Deletion of 13q (13q−) also was significantly less frequent in MM+/+ (23%) than in MM+/− and MM−/− (36% and 63%, respectively). The nonrandom distribution of chromosomal aberrations in the present series of MM tumors points to a novel, 14q32 translocation-independent pathogenetic pathway in plasma cell neoplasms. © 2005 Wiley-Liss, Inc. | ||
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