Long-term remission in a patient with heavily pretreated, advanced ovarian cancer achieved by bevacizumab and metronomic cyclophosphamide treatment
Vascular endothelial growth factor seems to be a promoter of tumor progression for epithelial ovarian cancer. New drugs such as bevacizumab, either alone or in combination with metronomic chemotherapy, suppress tumor growth and have proved to be effective in various tumor types. We present a 60-year...
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| Main Authors: | , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
2011
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| In: |
Anti-cancer drugs
Year: 2011, Volume: 22, Issue: 10, Pages: 1030-1033 |
| ISSN: | 1473-5741 |
| DOI: | 10.1097/CAD.0b013e32834a62b4 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/CAD.0b013e32834a62b4 Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/anti-cancerdrugs/Fulltext/2011/11000/Long_term_remission_in_a_patient_with_heavily.12.aspx 
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| Author Notes: | Julia Aigner, Esther Bischofs, Peter Hallscheidt, Christof Sohn, Andreas Schneeweiss and Michael Eichbaum |
| Summary: | Vascular endothelial growth factor seems to be a promoter of tumor progression for epithelial ovarian cancer. New drugs such as bevacizumab, either alone or in combination with metronomic chemotherapy, suppress tumor growth and have proved to be effective in various tumor types. We present a 60-year-old patient with heavily pretreated, recurrent epithelial ovarian cancer, who received bevacizumab (10 mg/m2) every 2 weeks in combination with metronomic administered low-dose cyclophosphamide (50 mg/day orally) after failing four explorative laparotomies and multiple chemotherapy regimes. At the time of writing, February 2011, she was being treated with this combination therapy for 24 months and the progression-free survival still continues. Treatment of advanced, refractory epithelial ovarian cancer with bevacizumab in combination with low-dose cyclophosphamide could be a very effective salvage treatment option in heavily pretreated patients. |
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| Item Description: | Gesehen am 28.02.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1473-5741 |
| DOI: | 10.1097/CAD.0b013e32834a62b4 |