Bone marrow microcirculation analysis in multiple myeloma by contrast-enhanced dynamic magnetic resonance imaging
The aim of our study was to investigate the quantitative microcirculation parameters amplitude A (hypothetical intravascular volume) and exchange rate constant k21 (hypothetical vascular permeability) by contrast-enhanced dynamic magnetic resonance imaging (dMRI) as markers of angiogenesis in multip...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
[15 September 2001]
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| In: |
International journal of cancer
Year: 2001, Jahrgang: 93, Heft: 6, Pages: 862-868 |
| ISSN: | 1097-0215 |
| DOI: | 10.1002/ijc.1421 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1002/ijc.1421 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/ijc.1421 
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| Verfasserangaben: | Thomas M. Moehler, Hans Hawighorst, Kai Neben, Gerlinde Egerer, Jens Hillengass, Regina Max, Axel Benner, Anthony D. Ho, Gerhard van Kaick, Hartmut Goldschmidt |
| Zusammenfassung: | The aim of our study was to investigate the quantitative microcirculation parameters amplitude A (hypothetical intravascular volume) and exchange rate constant k21 (hypothetical vascular permeability) by contrast-enhanced dynamic magnetic resonance imaging (dMRI) as markers of angiogenesis in multiple myeloma (MM). Therefore lumbar spine and spina iliaca superior posterior of 16 normal controls and 41 patients with active MM were assessed using a dMRI protocol with a pump controlled bolus infusion of Gadolinium-DTPA. Pharmacokinetic parameters, amplitude A and exchange rate constant k21 were calculated according to a 2-compartment model. Color-coded parameter images were generated from pharmacokinetic data analysis and superimposed onto the conventional MR images. Amplitude A and k21 parameters were significantly increased in patients with MM compared with controls (p = 0.001; median Actr, 0.2 [range, 0.09-0.4]; median AMM, 0.93 [range, 0.2-2.2]; median k21ctr, 0.09 min−1 [range, 0.03-0.9]; median k21MM, 4.58 [range, 0.22-23.8]). Within the group of MM patients the pattern of color-coded parameter images were found to be either of “diffuse” (n = 13, 31%) or “focal” (n = 28, 69%) type of distribution of microcirculation. Comparison of amplitude A in patients with “focal” vs. “diffuse” pattern of the pharmacokinetic maps revealed a significant increase in the median of amplitude A in the “focal” group. Amplitude A values allowed a classification of patients according to severe osteolytic bone involvement (p = 0.023) with the best cutoff value of 0.7 for amplitude A. Downmodulation of amplitude A was observed in a MM patient treated with standard VAD chemotherapy. Our data demonstrate that dMRI is a novel imaging technique for the detection and monitoring of MM bone lesions. It provides independent evidence for angiogenesis in MM. © 2001 Wiley-Liss, Inc. |
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| Beschreibung: | First published: 13 August 2001 Gesehen am 01.03.2022 |
| Beschreibung: | Online Resource |
| ISSN: | 1097-0215 |
| DOI: | 10.1002/ijc.1421 |