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Gap junctions between interneurons are required for normal spatial coding in the hippocampus and short-term spatial memory

Gap junctions containing connexin 36 electrically couple interneurons in many brain regions and synchronize their activity. We used connexin-36 knock-out mice (Cx36−/−) to study the importance of electrical coupling between interneurons for spatial coding in the hippocampus and for different forms o...

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Hauptverfasser: Allen, Kevin (VerfasserIn) , Fuchs, Elke C. (VerfasserIn) , Jaschonek, Hannah (VerfasserIn) , Bannerman, David M. (VerfasserIn) , Monyer, Hannah (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: April 27, 2011
In: The journal of neuroscience
Year: 2011, Jahrgang: 31, Heft: 17, Pages: 6542-6552
ISSN:1529-2401
DOI:10.1523/JNEUROSCI.6512-10.2011
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1523/JNEUROSCI.6512-10.2011
Verlag, lizenzpflichtig, Volltext: https://www.jneurosci.org/content/31/17/6542
Volltext
Verfasserangaben:Kevin Allen, Elke C. Fuchs, Hannah Jaschonek, David M. Bannerman, and Hannah Monyer
Beschreibung
Zusammenfassung:Gap junctions containing connexin 36 electrically couple interneurons in many brain regions and synchronize their activity. We used connexin-36 knock-out mice (Cx36−/−) to study the importance of electrical coupling between interneurons for spatial coding in the hippocampus and for different forms of hippocampus-dependent spatial memory. Recordings in behaving mice revealed that the spatial selectivity of hippocampal pyramidal neurons was reduced and less stable in Cx36−/− mice. Altered network activity was reflected in slower theta oscillations in the mutants. Temporal coding, assessed by determining the presence and characteristics of theta phase precession, had different dynamics in Cx36−/− mice compared with controls. At the behavioral level, Cx36−/− mice displayed impaired short-term spatial memory but normal spatial reference memory. These results highlight the functional role of electrically coupled interneurons for spatial coding and cognition. Moreover, they suggest that the precise spatial selectivity of place cells is not essential for normal performance on spatial tasks assessing associative long-term memory.
Beschreibung:Gesehen am 01.03.2022
Beschreibung:Online Resource
ISSN:1529-2401
DOI:10.1523/JNEUROSCI.6512-10.2011

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