Cover Image

Retinal and retinol are potential regulators of gene expression in the keratinocyte cell line HaCaT

Please cite this paper as: Retinal and retinol are potential regulators of gene expression in the keratinocyte cell line HaCaT. Experimental Dermatology 2010. Abstract: Vitamin A is a pivotal regulator of differentiation and growth of developing and adult skin. Retinoic acid is the major physiologic...

Full description

Saved in:
Bibliographic Details
Main Authors: Amann, Philipp M. (Author) , Schadendorf, Dirk (Author) , Owen, Robert (Author) , Korn, Bernhard (Author) , Eichmüller, Stefan B. (Author) , Bazhin, Alexandr V. (Author)
Format: Article (Journal)
Language:English
Published: 2011
In: Experimental dermatology
Year: 2011, Volume: 20, Issue: 4, Pages: 373-375
ISSN:1600-0625
DOI:10.1111/j.1600-0625.2010.01127.x
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1600-0625.2010.01127.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0625.2010.01127.x
Get full text
Author Notes:Philipp M. Amann, Dirk Schadendorf, Robert W. Owen, Bernhard Korn, Stefan B. Eichmüller and Alexandr V. Bazhin
Description
Summary:Please cite this paper as: Retinal and retinol are potential regulators of gene expression in the keratinocyte cell line HaCaT. Experimental Dermatology 2010. Abstract: Vitamin A is a pivotal regulator of differentiation and growth of developing and adult skin. Retinoic acid is the major physiologically active form of vitamin A regulating the expression of different genes through retinoic acid nuclear receptors. Here, we present evidence that other vitamin A derivates - retinol and retinal - are also capable of functioning as regulators of gene expression in the keratinocyte cell line HaCaT. We have shown that all-trans retinol (ATRol) and all-trans retinal (ATRal) are capable of modulating gene expression in keratinocytes, which is not because of vitamin A metabolism in the cells, and retinol and retinal modulate gene expression through nuclear receptors: retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Based on the data, we propose that ATRol and all-trans retinal, in addition to all-trans retinoic acid, can function as important regulators of gene expression manifesting their effect through the nuclear receptors RARs and RXRs.
Item Description:First published: 31 August 2010
Gesehen am 02.03.2022
Physical Description:Online Resource
ISSN:1600-0625
DOI:10.1111/j.1600-0625.2010.01127.x

Similar Items