Retinal and retinol are potential regulators of gene expression in the keratinocyte cell line HaCaT
Please cite this paper as: Retinal and retinol are potential regulators of gene expression in the keratinocyte cell line HaCaT. Experimental Dermatology 2010. Abstract: Vitamin A is a pivotal regulator of differentiation and growth of developing and adult skin. Retinoic acid is the major physiologic...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2011
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| In: |
Experimental dermatology
Year: 2011, Jahrgang: 20, Heft: 4, Pages: 373-375 |
| ISSN: | 1600-0625 |
| DOI: | 10.1111/j.1600-0625.2010.01127.x |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1600-0625.2010.01127.x Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0625.2010.01127.x 
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| Verfasserangaben: | Philipp M. Amann, Dirk Schadendorf, Robert W. Owen, Bernhard Korn, Stefan B. Eichmüller and Alexandr V. Bazhin |
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| 245 | 1 | 0 | |a Retinal and retinol are potential regulators of gene expression in the keratinocyte cell line HaCaT |c Philipp M. Amann, Dirk Schadendorf, Robert W. Owen, Bernhard Korn, Stefan B. Eichmüller and Alexandr V. Bazhin |
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| 520 | |a Please cite this paper as: Retinal and retinol are potential regulators of gene expression in the keratinocyte cell line HaCaT. Experimental Dermatology 2010. Abstract: Vitamin A is a pivotal regulator of differentiation and growth of developing and adult skin. Retinoic acid is the major physiologically active form of vitamin A regulating the expression of different genes through retinoic acid nuclear receptors. Here, we present evidence that other vitamin A derivates - retinol and retinal - are also capable of functioning as regulators of gene expression in the keratinocyte cell line HaCaT. We have shown that all-trans retinol (ATRol) and all-trans retinal (ATRal) are capable of modulating gene expression in keratinocytes, which is not because of vitamin A metabolism in the cells, and retinol and retinal modulate gene expression through nuclear receptors: retinoic acid receptors (RARs) and retinoid X receptors (RXRs). Based on the data, we propose that ATRol and all-trans retinal, in addition to all-trans retinoic acid, can function as important regulators of gene expression manifesting their effect through the nuclear receptors RARs and RXRs. | ||
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