Spectratype analysis of clonal T cell expansion in murine experimental stroke
T lymphocytes are major contributors to post-ischemic neuroinflammation following ischemic stroke. However, the mode of postischemic T cell activation remains a controversial issue. Therefore, this study aimed to directly investigate antigen-dependent clonal T cell expansion after experimental brain...
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| Main Authors: | , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
24 February 2013
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| In: |
Journal of neuroimmunology
Year: 2013, Volume: 257, Issue: 1-2, Pages: 46-52 |
| ISSN: | 1872-8421 |
| DOI: | 10.1016/j.jneuroim.2013.01.013 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jneuroim.2013.01.013 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165572813000271 
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| Author Notes: | Arthur Liesz, Simone Karcher, Roland Veltkamp |
| Summary: | T lymphocytes are major contributors to post-ischemic neuroinflammation following ischemic stroke. However, the mode of postischemic T cell activation remains a controversial issue. Therefore, this study aimed to directly investigate antigen-dependent clonal T cell expansion after experimental brain ischemia using spectratype/immunoscope analysis. We detected clonal T cell expansion in ischemic brains and to a lesser extent in secondary lymphatic organs and characterized its time course. This is the first study presenting direct evidence of clonal T cell expansion after stroke — however, with delayed kinetics that make antigen-dependent mechanisms unlikely in acute post-ischemic neuroinflammation. |
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| Item Description: | Gesehen am 02.03.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1872-8421 |
| DOI: | 10.1016/j.jneuroim.2013.01.013 |