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Angiotensin-converting enzyme insertion/deletion polymorphism in patients with acute and chronic pancreatitis

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Background - Reduction in angiotensin-converting enzyme (ACE) activity has been shown to attenuate pancreatic stellate cell activation and pancreatic fibrosis and suggested as a potential treatment for chronic pancreatitis. The ACE gene insertion/deletion (I/D) polymorphism in intron 16 accounts for...

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Main Authors: Hucl, Tomas (Author) , Kylanpää, Marja-Leena (Author) , Künzli, Beat (Author) , Witt, Heiko B. G. (Author) , Lempinen, Marko (Author) , Schneider, Alexander (Author) , Kemppainen, Esko (Author) , Löhr, J.-Matthias (Author) , Haas, Stephan (Author) , Friess, Helmut (Author) , Ockenga, Johann (Author) , Rosendahl, Jonas (Author) , Schulz, Hans-Ulrich (Author) , Gress, Thomas (Author) , Singer, Manfred V. (Author) , Pfützer, Roland (Author)
Format: Article (Journal)
Language:English
Published: 2009
In: European journal of gastroenterology & hepatology
Year: 2009, Volume: 21, Issue: 9, Pages: 1032-1035
ISSN:1473-5687
DOI:10.1097/MEG.0b013e328326f586
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1097/MEG.0b013e328326f586
Verlag, lizenzpflichtig, Volltext: https://journals.lww.com/eurojgh/Fulltext/2009/09000/Angiotensin_converting_enzyme_insertion_deletion.11.aspx
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Author Notes:Tomas Hucl, Marja-Leena Kylanpää, Beat Künzli, Heiko Witt, Marko Lempinen, Alexander Schneider, Esko Kemppainen, Matthias Löhr, Stephan L. Haas, Helmut Friess, Johann Ockenga, Jonas Rosendahl, Hans-Ulrich Schulz, Thomas Gress, Manfred V. Singer and Roland H. Pfützer
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Summary:Background - Reduction in angiotensin-converting enzyme (ACE) activity has been shown to attenuate pancreatic stellate cell activation and pancreatic fibrosis and suggested as a potential treatment for chronic pancreatitis. The ACE gene insertion/deletion (I/D) polymorphism in intron 16 accounts for nearly half the variation in serum ACE levels. This study determined the frequency of the I/D polymorphism in patients with acute and chronic pancreatitis. - Methods - In total, 887 patients (346 with alcoholic, 443 with nonalcoholic, and 98 with acute pancreatitis) were enrolled, and were compared with 1294 healthy controls. Genotyping of the I/D polymorphism was performed by PCR or melting curve analyses. - Results - No significant differences were found in the prevalence of the ACE-deletion genotype frequencies when patients with alcoholic (27.5%), nonalcoholic (26.4%), and acute pancreatitis (32.7%) were compared with controls (26.9%). Likewise, allele frequencies of the ACE deletion polymorphism were not significantly different in patients with alcoholic (53.8%), nonalcoholic (50.6%), and acute pancreatitis (54.1%) and controls (52.7%). - Conclusion - The I/D polymorphism of the ACE gene was not found to be associated with acute and chronic pancreatitis.
Item Description:Gesehen am 08.03.2022
Physical Description:Online Resource
ISSN:1473-5687
DOI:10.1097/MEG.0b013e328326f586

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