Association of plasma biomarkers, p-tau181, glial fibrillary acidic protein, and neurofilament light, with intermediate and long-term clinical Alzheimer's disease risk: results from a prospective cohort followed over 17 years

Blood biomarkers for Alzheimer's disease (AD) are the future of AD risk assessment. The aim of this study was to determine the association between plasma-measured phosphorylated tau (p-tau181), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) levels and risk of clinical AD...

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Main Authors: Stocker, Hannah (Author) , Beyer, Léon (Author) , Perna, Laura (Author) , Rujescu, Dan (Author) , Holleczek, Bernd (Author) , Beyreuther, Konrad (Author) , Stockmann, Julia (Author) , Schöttker, Ben (Author) , Gerwert, Klaus (Author) , Brenner, Hermann (Author)
Format: Article (Journal)
Language:English
Published: 14 January 2023
In: Alzheimer's and dementia
Year: 2023, Volume: 19, Pages: 25-35
ISSN:1552-5279
DOI:10.1002/alz.12614
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1002/alz.12614
Verlag, kostenfrei, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/alz.12614
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Author Notes:Hannah Stocker, Léon Beyer, Laura Perna, Dan Rujescu, Bernd Holleczek, Konrad Beyreuther, Julia Stockmann, Ben Schöttker, Klaus Gerwert, Hermann Brenner
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Summary:Blood biomarkers for Alzheimer's disease (AD) are the future of AD risk assessment. The aim of this study was to determine the association between plasma-measured phosphorylated tau (p-tau181), glial fibrillary acidic protein (GFAP), and neurofilament light (NfL) levels and risk of clinical AD incidence with consideration to the impact of cardiovascular health.
Item Description:Online veröffentlicht: 02. März 2022
Gesehen am 09.03.2022
Physical Description:Online Resource
ISSN:1552-5279
DOI:10.1002/alz.12614