Basic symptoms and gray matter volumes of patients at clinical high risk for psychosis
Background - Clinical high-risk (CHR) for psychosis is indicated by ultra-high risk (UHR) and basic symptom (BS) criteria; however, conversion rates are highest when both UHR and BS criteria are fulfilled (UHR&BS). While BSs are considered the most immediate expression of neurobiological aberrat...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2021
|
| In: |
Psychological medicine
Year: 2021, Volume: 51, Issue: 15, Pages: 2666-2674 |
| ISSN: | 1469-8978 |
| DOI: | 10.1017/S0033291720001282 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1017/S0033291720001282 Verlag, lizenzpflichtig, Volltext: https://www.cambridge.org/core/journals/psychological-medicine/article/basic-symptoms-and-gray-matter-volumes-of-patients-at-clinical-high-risk-for-psychosis/11EEECCAE85F576A96C3D29AA1C6098A 
|
| Author Notes: | Daniela Hubl, Chantal Michel, Frauke Schultze-Lutter, Martinus Hauf, Benno G. Schimmelmann, Michael Kaess and Jochen Kindler |
| Summary: | Background - Clinical high-risk (CHR) for psychosis is indicated by ultra-high risk (UHR) and basic symptom (BS) criteria; however, conversion rates are highest when both UHR and BS criteria are fulfilled (UHR&BS). While BSs are considered the most immediate expression of neurobiological aberrations underlying the development of psychosis, research on neurobiological correlates of BS is scarce. - - Methods - We investigated gray matter volumes (GMV) of 20 regions of interest (ROI) previously associated with UHR criteria in 90 patients from the Bern early detection service: clinical controls (CC), first-episode psychosis (FEP), UHR, BS and UHR&BS. We expected lowest GMV in FEP and UHR&BS, and highest volume in CC with UHR and BS in-between. - - Results - Significantly, lower GMV was detected in FEP and UHR&BS patients relative to CC with no other significant between-group differences. When ROIs were analyzed separately, seven showed a significant group effect (FDR corrected), with five (inferior parietal, medial orbitofrontal, lateral occipital, middle temporal, precuneus) showing significantly lower GM volume in the FEP and/or UHR&BS groups than in the CC group (Bonferroni corrected). In the CHR group, only COGDIS scores correlated negatively with cortical volumes. - - Conclusions - This is the first study to demonstrate that patients who fulfill both UHR and BS criteria - a population that has been associated with higher conversion rates - exhibit more severe GMV reductions relative to those who satisfy BS or UHR criteria alone. This result was mediated by the BS in the UHR&BS group, as only the severity of BS was linked to GMV reductions. |
|---|---|
| Item Description: | First published online: 14 May 2020 Gesehen am 04.05.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1469-8978 |
| DOI: | 10.1017/S0033291720001282 |