Racial and socioeconomic disparity associates with differences in cardiac DNA methylation among men with end-stage heart failure
Heart failure (HF) is a multifactorial syndrome that remains a leading cause of worldwide morbidity. Despite its high prevalence, only half of patients with HF respond to guideline-directed medical management, prompting therapeutic efforts to confront the molecular underpinnings of its heterogeneity...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
March 26, 2021
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| In: |
American journal of physiology. Heart and circulatory physiology
Year: 2021, Volume: 320, Issue: 5, Pages: H2066-H2079 |
| ISSN: | 1522-1539 |
| DOI: | 10.1152/ajpheart.00036.2021 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1152/ajpheart.00036.2021 Verlag, lizenzpflichtig, Volltext: https://journals.physiology.org/doi/full/10.1152/ajpheart.00036.2021 |
| Author Notes: | Mark E. Pepin, Chae-Myeong Ha, Luke A. Potter, Sayan Bakshi, Joseph P. Barchue, Ayman Haj Asaad, Steven M. Pogwizd, Salpy V. Pamboukian, Bertha A. Hidalgo, Selwyn M. Vickers, Adam R. Wende |
| Summary: | Heart failure (HF) is a multifactorial syndrome that remains a leading cause of worldwide morbidity. Despite its high prevalence, only half of patients with HF respond to guideline-directed medical management, prompting therapeutic efforts to confront the molecular underpinnings of its heterogeneity. In the current study, we examined epigenetics as a yet unexplored source of heterogeneity among patients with end-stage HF. |
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| Item Description: | Gesehen am 17.03.2022 |
| Physical Description: | Online Resource |
| ISSN: | 1522-1539 |
| DOI: | 10.1152/ajpheart.00036.2021 |