Common T-cell-receptor motifs and features in patients with cytomegalovirus (CMV)-seronegative end-stage renal disease receiving a peptide caccination against CMV
After solid-organ transplantation, reactivation of the cytomegalovirus (CMV) is often observed in seronegative patients and associated with a high risk of disease and mortality. CMV-specific T cells can prevent CMV reactivation. In a phase 1 trial, CMV-seronegative patients with end-stage renal dise...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 January 2022
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| In: |
International journal of molecular sciences
Year: 2022, Volume: 23, Issue: 3, Pages: 1-12 |
| ISSN: | 1422-0067 |
| DOI: | 10.3390/ijms23031029 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/ijms23031029 Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/1422-0067/23/3/1029 
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| Author Notes: | Lukas Bunse, Claudia Sommerer, Chin Leng Tan, Felix Korell, Anita Schmitt, Angela Hückelhoven-Krauss, Brigitte Neuber, Thomas Mertens, Michael Platten, Edward W. Green, Martin Zeier and Michael Schmitt |
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| 245 | 1 | 0 | |a Common T-cell-receptor motifs and features in patients with cytomegalovirus (CMV)-seronegative end-stage renal disease receiving a peptide caccination against CMV |c Lukas Bunse, Claudia Sommerer, Chin Leng Tan, Felix Korell, Anita Schmitt, Angela Hückelhoven-Krauss, Brigitte Neuber, Thomas Mertens, Michael Platten, Edward W. Green, Martin Zeier and Michael Schmitt |
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| 520 | |a After solid-organ transplantation, reactivation of the cytomegalovirus (CMV) is often observed in seronegative patients and associated with a high risk of disease and mortality. CMV-specific T cells can prevent CMV reactivation. In a phase 1 trial, CMV-seronegative patients with end-stage renal disease listed for kidney transplantation were subjected to CMV phosphoprotein 65 (CMVpp65) peptide vaccination and further investigated for T-cell responses. To this end, CMV-specific CD8+ T cells were characterized by bulk T-cell-receptor (TCR) repertoire sequencing and combined single-cell RNA and TCR sequencing. In patients mounting an immune response to the vaccine, a common SYE(N)E TCR motif known to bind CMVpp65 was detected. CMV-peptide-vaccination-responder patients had TCR features distinct from those of non-responders. In a non-responder patient, a monoclonal inflammatory T-cell response was detected upon CMV reactivation. The identification of vaccine-induced CMV-reactive TCRs motifs might facilitate the development of cellular therapies for patients wait-listed for kidney transplantation. | ||
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