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Immune checkpoint blockade for metastatic uveal melanoma: re-induction following resistance or toxicity

Re-induction with immune checkpoint blockade (ICB) needs to be considered in many patients with uveal melanoma (UM) due to limited systemic treatment options. Here, we provide hitherto the first analysis of ICB re-induction in UM. A total of 177 patients with metastatic UM treated with ICB were incl...

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Main Authors: Koch, Elias A. T. (Author) , Petzold, Anne (Author) , Wessely, Anja (Author) , Dippel, Edgar (Author) , Gesierich, Anja (Author) , Gutzmer, Ralf (Author) , Hassel, Jessica C. (Author) , Haferkamp, Sebastian (Author) , Kähler, Katharina C. (Author) , Knorr, Harald (Author) , Kreuzberg, Nicole (Author) , Leiter-Stöppke, Ulrike (Author) , Loquai, Carmen (Author) , Meier, Friedegund (Author) , Meissner, Markus (Author) , Mohr, Peter (Author) , Pföhler, Claudia (Author) , Rahimi, Farnaz (Author) , Schadendorf, Dirk (Author) , Schell, Beatrice (Author) , Schlaak, Max (Author) , Terheyden, Patrick (Author) , Thoms, Kai-Martin (Author) , Schuler-Thurner, Beatrice (Author) , Ugurel, Selma (Author) , Ulrich, Jens (Author) , Utikal, Jochen (Author) , Weichenthal, Michael (Author) , Ziller, Fabian (Author) , Berking, Carola (Author) , Heppt, Markus V. (Author)
Format: Article (Journal)
Language:English
Published: 20 January 2022
In: Cancers
Year: 2022, Volume: 14, Issue: 3, Pages: 1-11
ISSN:2072-6694
DOI:10.3390/cancers14030518
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3390/cancers14030518
Verlag, lizenzpflichtig, Volltext: https://www.mdpi.com/2072-6694/14/3/518
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Author Notes:Elias A.T. Koch, Anne Petzold, Anja Wessely, Edgar Dippel, Anja Gesierich, Ralf Gutzmer, Jessica C. Hassel, Sebastian Haferkamp, Katharina C. Kähler, Harald Knorr, Nicole Kreuzberg, Ulrike Leiter, Carmen Loquai, Friedegund Meier, Markus Meissner, Peter Mohr, Claudia Pföhler, Farnaz Rahimi, Dirk Schadendorf, Beatrice Schell, Max Schlaak, Patrick Terheyden, Kai-Martin Thoms, Beatrice Schuler-Thurner, Selma Ugurel, Jens Ulrich, Jochen Utikal, Michael Weichenthal, Fabian Ziller, Carola Berking, Markus V. Heppt and on behalf of the German Dermatologic Cooperative Oncology Group (DeCOG, Committee Ocular Melanoma)
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Summary:Re-induction with immune checkpoint blockade (ICB) needs to be considered in many patients with uveal melanoma (UM) due to limited systemic treatment options. Here, we provide hitherto the first analysis of ICB re-induction in UM. A total of 177 patients with metastatic UM treated with ICB were included from German skin cancer centers and the German national skin cancer registry (ADOReg). To investigate the impact of ICB re-induction, two cohorts were compared: patients who received at least one ICB re-induction (cohort A, n = 52) versus those who received only one treatment line of ICB (cohort B, n = 125). In cohort A, a transient benefit of overall survival (OS) was observed at 6 and 12 months after the treatment start of ICB. There was no significant difference in OS between both groups (p = 0.1) with a median OS of 16.2 months (cohort A, 95% CI: 11.1-23.8) versus 9.4 months (cohort B, 95% CI: 6.1-14.9). Patients receiving re-induction of ICB (cohort A) had similar response rates compared to those receiving ICB once. Re-induction of ICB may yield a clinical benefit for a small subgroup of patients even after resistance or development of toxicities.
Item Description:Gesehen am 25.03.2022
Physical Description:Online Resource
ISSN:2072-6694
DOI:10.3390/cancers14030518

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