Cover Image

The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides

This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave-assisted synthesis...

Full description

Saved in:
Bibliographic Details
Main Authors: Pham, Truc Lam (Author) , Zilke, Jennifer (Author) , Müller, Christine Charlotte (Author) , Thomas, Franziska (Author)
Format: Article (Journal)
Language:English
Published: 18 Feb 2022
In: RSC chemical biology
Year: 2022, Pages: 1-5
ISSN:2633-0679
DOI:10.1039/D1CB00252J
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1039/D1CB00252J
Verlag, kostenfrei, Volltext: https://pubs.rsc.org/en/content/articlelanding/2022/cb/d1cb00252j
Get full text
Author Notes:Truc Lam Pham, Jennifer Zilke, Christine Charlotte Müller and Franziska Thomas
Description
Summary:This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave-assisted synthesis of CSY-protected peptides, and CSY cleavage in partially folded or aggregation-prone peptides.
Item Description:Gesehen am 24.03.2022
Physical Description:Online Resource
ISSN:2633-0679
DOI:10.1039/D1CB00252J

Similar Items