Cover Image

Endothelin B receptor-deficient rats as a subtraction model to study the cerebral endothelin system

Endothelins, due to their potent vasoactivity and mitogenicity, appear to play an important role in the brain, where all components of the endothelin system, peptides, receptors and converting enzyme, are expressed. To further elucidate the role of the cerebral endothelin system, astrocytes and cere...

Full description

Saved in:
Bibliographic Details
Main Authors: Ehrenreich, Hannelore (Author) , Oldenburg, J. (Author) , Hasselblatt, M. (Author) , Herms, J. (Author) , Dembowski, C. (Author) , Löffler, B.-M. (Author) , Brück, W. (Author) , Kamrowski-Kruck, H. (Author) , Gall, S. (Author) , Sirén, A.-L. (Author) , Schilling, Lothar (Author)
Format: Article (Journal)
Language:English
Published: 4 May 1999
In: Neuroscience
Year: 1999, Volume: 91, Issue: 3, Pages: 1067-1075
ISSN:1873-7544
DOI:10.1016/S0306-4522(98)00663-0
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0306-4522(98)00663-0
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0306452298006630
Get full text
Author Notes:H. Ehrenreich, J. Oldenburg, M. Hasselblatt, J. Herms, C. Dembowski, B.-M. Löffler, W. Brück, H. Kamrowski-Kruck, S. Gall, A.-L. Sirén and L. Schilling
Description
Summary:Endothelins, due to their potent vasoactivity and mitogenicity, appear to play an important role in the brain, where all components of the endothelin system, peptides, receptors and converting enzyme, are expressed. To further elucidate the role of the cerebral endothelin system, astrocytes and cerebral vessels from sl/sl rats, devoid of functional endothelin B receptors, have been employed. Astrocytes from sl/sl rats display the following abnormalities as compared to wild-type (+/+) cells: (i) elevated basal extracellular endothelin-1 levels; (ii) exclusive presence of functional endothelin A receptors; (iii) increased extracellular endothelin-1 levels upon endothelin A receptor blockade; (iv) augmented basal endothelin-converting enzyme activity; (v) altered calcium response to endothelin-1. The basilar artery of sl/sl rats shows an enhanced constricting response to endothelin-1 and fails to dilate in response to endothelin-3, shifting the endothelin vasomotor balance to constriction. In conclusion, endothelin B receptors may be essential for restricting extracellular endothelin-1 levels in the brain, as well as for a balanced cerebral vasomotor action of endothelins.
Item Description:Gesehen am 24.03.2022
Physical Description:Online Resource
ISSN:1873-7544
DOI:10.1016/S0306-4522(98)00663-0

Similar Items