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Endothelin B receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus

The dentate gyrus retains neuronal proliferative potential throughout life. Using immature endothelin B receptor-deficient (sl/sl) rats, a rabbit model of pneumococcal meningitis and autopsy brains from humans who died from pneumococcal meningitis, we explored the role of endothelin B receptors in p...

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Main Authors: Ehrenreich, Hannelore (Author) , Nau, R. (Author) , Dembowski, C. (Author) , Hasselblatt, M. (Author) , Barth, Martin (Author) , Hahn, A. (Author) , Schilling, Lothar (Author) , Sirén, A. -L. (Author) , Brück, W. (Author)
Format: Article (Journal)
Language:English
Published: 28 December 1999
In: Neuroscience
Year: 1999, Volume: 95, Issue: 4, Pages: 993-1001
ISSN:1873-7544
DOI:10.1016/S0306-4522(99)00507-2
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0306-4522(99)00507-2
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0306452299005072
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Author Notes:H. Ehrenreich, R. Nau, C. Dembowski, M. Hasselblatt, M. Barth, A. Hahn, L. Schilling, A.-L. Sirén and W. Brück
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Summary:The dentate gyrus retains neuronal proliferative potential throughout life. Using immature endothelin B receptor-deficient (sl/sl) rats, a rabbit model of pneumococcal meningitis and autopsy brains from humans who died from pneumococcal meningitis, we explored the role of endothelin B receptors in physiological and pathological neuronal apoptosis in the dentate gyrus. At postnatal days 3-4, the rate of apoptosis in the dentate gyrus was high in all rats, declining to low levels in wild-type rats (+/+) on days 14 and 22, but remaining high in both homozygous (sl/sl) and heterozygous (sl/+) endothelin B receptor-deficient rats. Increased apoptosis was not significantly compensated for by neuronal proliferation. Hippocampal neuronal cultures also exhibited genotype-dependent apoptosis with the highest rate in neurons from homozygous endothelin B receptor-deficient (sl/sl) rats. In rabbit and human pneumococcal meningitis, increased apoptosis in the dentate gyrus was associated with loss of neuronal endothelin B receptor immunoreactivity. In conclusion, endothelin B receptors appear to act as neuronal survival factors in the dentate gyrus in rodents and man, both during postnatal development and under pathological conditions.
Item Description:Gesehen am 24.03.2022
Physical Description:Online Resource
ISSN:1873-7544
DOI:10.1016/S0306-4522(99)00507-2

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