Endothelin B receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus
The dentate gyrus retains neuronal proliferative potential throughout life. Using immature endothelin B receptor-deficient (sl/sl) rats, a rabbit model of pneumococcal meningitis and autopsy brains from humans who died from pneumococcal meningitis, we explored the role of endothelin B receptors in p...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
28 December 1999
|
| In: |
Neuroscience
Year: 1999, Volume: 95, Issue: 4, Pages: 993-1001 |
| ISSN: | 1873-7544 |
| DOI: | 10.1016/S0306-4522(99)00507-2 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0306-4522(99)00507-2 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0306452299005072 
|
| Author Notes: | H. Ehrenreich, R. Nau, C. Dembowski, M. Hasselblatt, M. Barth, A. Hahn, L. Schilling, A.-L. Sirén and W. Brück |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1796588512 | ||
| 003 | DE-627 | ||
| 005 | 20220820152906.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 220324s1999 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/S0306-4522(99)00507-2 |2 doi | |
| 035 | |a (DE-627)1796588512 | ||
| 035 | |a (DE-599)KXP1796588512 | ||
| 035 | |a (OCoLC)1341457950 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Ehrenreich, Hannelore |d 1955- |e VerfasserIn |0 (DE-588)131459910 |0 (DE-627)50945755X |0 (DE-576)298491982 |4 aut | |
| 245 | 1 | 0 | |a Endothelin B receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus |c H. Ehrenreich, R. Nau, C. Dembowski, M. Hasselblatt, M. Barth, A. Hahn, L. Schilling, A.-L. Sirén and W. Brück |
| 264 | 1 | |c 28 December 1999 | |
| 300 | |a 9 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 24.03.2022 | ||
| 520 | |a The dentate gyrus retains neuronal proliferative potential throughout life. Using immature endothelin B receptor-deficient (sl/sl) rats, a rabbit model of pneumococcal meningitis and autopsy brains from humans who died from pneumococcal meningitis, we explored the role of endothelin B receptors in physiological and pathological neuronal apoptosis in the dentate gyrus. At postnatal days 3-4, the rate of apoptosis in the dentate gyrus was high in all rats, declining to low levels in wild-type rats (+/+) on days 14 and 22, but remaining high in both homozygous (sl/sl) and heterozygous (sl/+) endothelin B receptor-deficient rats. Increased apoptosis was not significantly compensated for by neuronal proliferation. Hippocampal neuronal cultures also exhibited genotype-dependent apoptosis with the highest rate in neurons from homozygous endothelin B receptor-deficient (sl/sl) rats. In rabbit and human pneumococcal meningitis, increased apoptosis in the dentate gyrus was associated with loss of neuronal endothelin B receptor immunoreactivity. In conclusion, endothelin B receptors appear to act as neuronal survival factors in the dentate gyrus in rodents and man, both during postnatal development and under pathological conditions. | ||
| 650 | 4 | |a apoptosis | |
| 650 | 4 | |a dentate gyrus | |
| 650 | 4 | |a endothelin | |
| 650 | 4 | |a endothelin B receptors | |
| 650 | 4 | |a proliferation | |
| 700 | 1 | |a Nau, R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Dembowski, C. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hasselblatt, M. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Barth, Martin |d 1971- |e VerfasserIn |0 (DE-588)1038041279 |0 (DE-627)756608635 |0 (DE-576)392061805 |4 aut | |
| 700 | 1 | |a Hahn, A. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Schilling, Lothar |d 1954- |e VerfasserIn |0 (DE-588)1028374690 |0 (DE-627)730623521 |0 (DE-576)375909893 |4 aut | |
| 700 | 1 | |a Sirén, A. -L. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brück, W. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Neuroscience |d Amsterdam [u.a.] : Elsevier Science, 1976 |g 95(1999), 4, Seite 993-1001 |h Online-Ressource |w (DE-627)306588625 |w (DE-600)1498423-4 |w (DE-576)081953089 |x 1873-7544 |7 nnas |a Endothelin B receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus |
| 773 | 1 | 8 | |g volume:95 |g year:1999 |g number:4 |g pages:993-1001 |g extent:9 |a Endothelin B receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus |
| 856 | 4 | 0 | |u https://doi.org/10.1016/S0306-4522(99)00507-2 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0306452299005072 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20220324 | ||
| 993 | |a Article | ||
| 994 | |a 1999 | ||
| 998 | |g 1028374690 |a Schilling, Lothar |m 1028374690:Schilling, Lothar |d 60000 |d 62600 |e 60000PS1028374690 |e 62600PS1028374690 |k 0/60000/ |k 1/60000/62600/ |p 7 | ||
| 998 | |g 1038041279 |a Barth, Martin |m 1038041279:Barth, Martin |d 60000 |d 62600 |e 60000PB1038041279 |e 62600PB1038041279 |k 0/60000/ |k 1/60000/62600/ |p 5 | ||
| 999 | |a KXP-PPN1796588512 |e 4099323455 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"name":{"displayForm":["H. Ehrenreich, R. Nau, C. Dembowski, M. Hasselblatt, M. Barth, A. Hahn, L. Schilling, A.-L. Sirén and W. Brück"]},"recId":"1796588512","person":[{"given":"Hannelore","display":"Ehrenreich, Hannelore","role":"aut","family":"Ehrenreich"},{"given":"R.","display":"Nau, R.","role":"aut","family":"Nau"},{"display":"Dembowski, C.","given":"C.","role":"aut","family":"Dembowski"},{"role":"aut","family":"Hasselblatt","given":"M.","display":"Hasselblatt, M."},{"given":"Martin","display":"Barth, Martin","role":"aut","family":"Barth"},{"role":"aut","family":"Hahn","given":"A.","display":"Hahn, A."},{"family":"Schilling","role":"aut","display":"Schilling, Lothar","given":"Lothar"},{"family":"Sirén","role":"aut","display":"Sirén, A. -L.","given":"A. -L."},{"family":"Brück","role":"aut","given":"W.","display":"Brück, W."}],"note":["Gesehen am 24.03.2022"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title_sort":"Endothelin B receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus","title":"Endothelin B receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrus"}],"id":{"doi":["10.1016/S0306-4522(99)00507-2"],"eki":["1796588512"]},"physDesc":[{"extent":"9 S."}],"relHost":[{"language":["eng"],"part":{"volume":"95","year":"1999","text":"95(1999), 4, Seite 993-1001","pages":"993-1001","extent":"9","issue":"4"},"note":["Gesehen am 20.02.20"],"pubHistory":["1.1976 -"],"disp":"Endothelin B receptor deficiency is associated with an increased rate of neuronal apoptosis in the dentate gyrusNeuroscience","type":{"bibl":"periodical","media":"Online-Ressource"},"corporate":[{"role":"isb","display":"International Brain Research Organization"}],"recId":"306588625","title":[{"title":"Neuroscience","subtitle":"an international journal under the editorial direction of IBRO","title_sort":"Neuroscience"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["306588625"],"issn":["1873-7544"],"zdb":["1498423-4"]},"origin":[{"publisher":"Elsevier Science","dateIssuedDisp":"1976-","dateIssuedKey":"1976","publisherPlace":"Amsterdam [u.a.]"}]}],"origin":[{"dateIssuedDisp":"28 December 1999","dateIssuedKey":"1999"}]} | ||
| SRT | |a EHRENREICHENDOTHELIN2819 | ||