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Up-regulation of β-catenin in external auditory canal cholesteatoma

The external auditory canal cholesteatoma (EACC) is a rare disease with hyperproliferation and destructive growth in the adjacent structures. Down-regulation of β-catenin (key component of the zonula adherens) is a pivotal factor for loose tissue integrity and invasiveness. Transforming growth facto...

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Main Authors: Naim, Ramin (Author) , Chang, Ray C. (Author) , Anders, Clemens Frithjof (Author) , Sadick, Haneen (Author) , Riedel, Frank (Author) , Bayerl, Christiane (Author) , Bran, Gregor M. (Author) , Hörmann, Karl (Author)
Format: Article (Journal)
Language:English
Published: May 1, 2005
In: International journal of molecular medicine
Year: 2005, Volume: 15, Issue: 5, Pages: 801-804
ISSN:1791-244X
DOI:10.3892/ijmm.15.5.801
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.3892/ijmm.15.5.801
Verlag, lizenzpflichtig, Volltext: https://www.spandidos-publications.com/10.3892/ijmm.15.5.801
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Author Notes:Ramin Naim, Ray C. Chang, Clemens Anders, Haneen Sadick, Frank Riedel, Christiane Bayerl, Gregor Bran, Karl Hormann
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Summary:The external auditory canal cholesteatoma (EACC) is a rare disease with hyperproliferation and destructive growth in the adjacent structures. Down-regulation of β-catenin (key component of the zonula adherens) is a pivotal factor for loose tissue integrity and invasiveness. Transforming growth factor β1 (TGF-β1) was reported to decrease β-catenin in mammary epithelium. We investigated the abrogation of TGF-β1 and β-catenin expression in EACC culture cells. Cultured EACC-specimens were incubated with 6 µmol TGF-β1 antisense. After 48 h, expression of β-catenin was determined by means of immunohistochemistry. The cells showed an increased mural reactivity to β-catenin, and intracellular reactivity was unchanged. The untreated cells showed a loss of β-catenin expression at the membranes. The predominant membranous location after treatment with TGF-β1 antisense suggests increased tendency of the cells for tissue formation and strong cell-cell adhesion rather than migratory and invasive character, and thus TGF-β1 antisense application is a useful therapeutical strategy.
Item Description:Gesehen am 25.03.2022
Physical Description:Online Resource
ISSN:1791-244X
DOI:10.3892/ijmm.15.5.801

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