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Estriol induced squamous metaplasia on the nasal mucosa in patients with hereditary hemorrhagic telangiectasia

Background - The aim of this study was to evaluate by light and electron microscopy the effect of topical estriol on the nasal mucosa in patients with hereditary hemorrhagic telangiectasia (HHT). - Methods - Twelve patients were instructed to apply twice daily 0.1% estriol as a nose ointment over a...

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Main Authors: Sadick, Haneen (Author) , Bergler, Wolfgang F. (Author) , Oulmi-Kagermann, Jasmina (Author) , Naim, Ramin (Author) , Sadick, Maliha (Author) , Hörmann, Karl (Author) , Riedel, Frank (Author)
Format: Article (Journal)
Language:English
Published: [September-October 2005]
In: Archives of medical research
Year: 2005, Volume: 36, Issue: 5, Pages: 468-473
ISSN:1873-5487
DOI:10.1016/j.arcmed.2005.03.037
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.arcmed.2005.03.037
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0188440905001360
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Author Notes:Haneen Sadick, Wolfgang F. Bergler, Jasmina Oulmi-Kagermann, Ramin Naim, Maliha Sadick, Karl Hörmann, Frank Riedel
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Summary:Background - The aim of this study was to evaluate by light and electron microscopy the effect of topical estriol on the nasal mucosa in patients with hereditary hemorrhagic telangiectasia (HHT). - Methods - Twelve patients were instructed to apply twice daily 0.1% estriol as a nose ointment over a period of 12 months. Written consent was obtained from each patient, allowing biopsy specimens of the nasal mucosa to be taken prior to and 3, 6 and 12 months after estriol application. - Results - Metaplastic change of the nasal mucosa was observed 6 months after topical estriol application. The former ciliated columnar epithelium changed into a keratinizing squamous epithelium. The effect was reversible after discontinuation of estriol application. - Conclusions - For the first time, we could outline the effect of topical estriol on the nasal mucosa. These histomorphological findings, and the fact that estriol is a low-potency metabolite of estradiol, make estriol a valuable agent in the treatment of HHT patients.
Item Description:Gesehen am 25.03.2022
Physical Description:Online Resource
ISSN:1873-5487
DOI:10.1016/j.arcmed.2005.03.037

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